PMID: 11909834Mar 23, 2002Paper

Molecular characterization of ketolide-resistant erm(A)-carrying Staphylococcus aureus isolates selected in vitro by telithromycin, ABT-773, quinupristin and clindamycin

The Journal of Antimicrobial Chemotherapy
Franz-Josef SchmitzStefan Schwarz

Abstract

The aim of this study was to investigate whether a Staphylococcus aureus strain that carried an inducibly expressed erm(A) gene might exhibit resistance to the non-inducers telithromycin, ABT-773, clindamycin, quinupristin, dalfopristin or the combination quinupristin-dalfopristin after incubation in the presence of inhibitory concentrations of any of these compounds. Whenever resistant mutants were obtained, these were investigated for the molecular basis of the altered resistance phenotype. Resistant mutants were not selected with dalfopristin or quinupristin-dalfopristin, but were obtained with the other four agents. Irrespective of which drug was used for selection, all mutants were cross-resistant to clindamycin, quinupristin, telithromycin and ABT-773, and exhibited structural alterations in the erm(A) translational attenuator. The structural alterations observed included deletions of 14, 83, 121, 131, 147 or 157 bp, three different tandem duplications of 23, 25 or 26 bp, two different types of point mutation, as well as the insertion of IS256. All these alterations either completely prevented the formation of mRNA secondary structures in the erm(A) regulatory region or favoured the formation of those mRNA secondary struc...Continue Reading

References

Nov 1, 1992·Plasmid·K G DykeN el Solh
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·R Leclercq, P Courvalin
Apr 1, 1995·Antimicrobial Agents and Chemotherapy·B Weisblum
Mar 1, 1997·Antimicrobial Agents and Chemotherapy·S Kamimiya, B Weisblum
Jul 1, 1997·The Journal of Antimicrobial Chemotherapy·A BonnefoyJ F Chantot
Oct 24, 1998·The Journal of Antimicrobial Chemotherapy·T SchülinG M Eliopoulos
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·K MalathumB E Murray
Jun 25, 1999·The Journal of Antimicrobial Chemotherapy·W O ChungM C Roberts
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·C WerckenthinH Westh
Dec 3, 1999·Antimicrobial Agents and Chemotherapy·M C RobertsH Seppala
Dec 5, 2000·The Journal of Antimicrobial Chemotherapy·J M Hamilton-Miller, S Shah
Dec 5, 2000·The Journal of Antimicrobial Chemotherapy·J M AndrewsR Wise
Jun 16, 2001·Antimicrobial Agents and Chemotherapy·A M NiliusR K Flamm
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·M J MittenR K Flamm

❮ Previous
Next ❯

Citations

Jul 5, 2003·International Journal of Antimicrobial Agents·S BesierT A Wichelhaus
Feb 15, 2012·The Journal of Antimicrobial Chemotherapy·Yang WangJianzhong Shen
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Darren AbbanatKaren Bush
Jan 16, 2007·Clinical Microbiology Reviews·Florence DepardieuPatrice Courvalin
Dec 24, 2011·Annals of the New York Academy of Sciences·Joyce A Sutcliffe
Mar 11, 2006·International Journal of Medical Microbiology : IJMM·Stefan Schwarz, Corinna Kehrenberg
Jan 28, 2014·Veterinary Microbiology·Monika EntorfStefan Schwarz
May 16, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S G GatermannS Friedrich
Nov 3, 2016·Cold Spring Harbor Perspectives in Medicine·Stefan SchwarzBirte Vester
Aug 12, 2020·The Journal of Antimicrobial Chemotherapy·Valeria BortolaiaFrank M Aarestrup
Jan 13, 2018·Microbiology Spectrum·Engeline van DuijkerenStefan Schwarz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.