Abstract
The aim of this study was to investigate whether a Staphylococcus aureus strain that carried an inducibly expressed erm(A) gene might exhibit resistance to the non-inducers telithromycin, ABT-773, clindamycin, quinupristin, dalfopristin or the combination quinupristin-dalfopristin after incubation in the presence of inhibitory concentrations of any of these compounds. Whenever resistant mutants were obtained, these were investigated for the molecular basis of the altered resistance phenotype. Resistant mutants were not selected with dalfopristin or quinupristin-dalfopristin, but were obtained with the other four agents. Irrespective of which drug was used for selection, all mutants were cross-resistant to clindamycin, quinupristin, telithromycin and ABT-773, and exhibited structural alterations in the erm(A) translational attenuator. The structural alterations observed included deletions of 14, 83, 121, 131, 147 or 157 bp, three different tandem duplications of 23, 25 or 26 bp, two different types of point mutation, as well as the insertion of IS256. All these alterations either completely prevented the formation of mRNA secondary structures in the erm(A) regulatory region or favoured the formation of those mRNA secondary struc...Continue Reading
References
Nov 1, 1992·Plasmid·K G DykeN el Solh
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·R Leclercq, P Courvalin
Nov 1, 1990·Antimicrobial Agents and Chemotherapy·M E ByrneR A Skurray
Oct 20, 1988·Journal of Molecular Biology·P Sandler, B Weisblum
May 1, 1985·Journal of Bacteriology·E Murphy
Jan 1, 1984·CRC Critical Reviews in Biochemistry·D Dubnau
Feb 1, 1995·Antimicrobial Agents and Chemotherapy·H WesthV T Rosdahl
Apr 1, 1995·Antimicrobial Agents and Chemotherapy·B Weisblum
Mar 1, 1997·Antimicrobial Agents and Chemotherapy·S Kamimiya, B Weisblum
Jul 1, 1997·The Journal of Antimicrobial Chemotherapy·A BonnefoyJ F Chantot
May 6, 1998·Journal of Medical Microbiology·F J SchmitzM E Jones
Aug 1, 1998·The Journal of Antimicrobial Chemotherapy·J M Hamilton-Miller, S Shah
Oct 24, 1998·The Journal of Antimicrobial Chemotherapy·T SchülinG M Eliopoulos
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·K MalathumB E Murray
May 1, 1999·Antimicrobial Agents and Chemotherapy·G LinaJ Etienne
Jun 25, 1999·The Journal of Antimicrobial Chemotherapy·W O ChungM C Roberts
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·C WerckenthinH Westh
Dec 3, 1999·Antimicrobial Agents and Chemotherapy·M C RobertsH Seppala
Jun 6, 2000·The Journal of Antimicrobial Chemotherapy·F J SchmitzA C Fluit
Nov 4, 2000·The Journal of Antimicrobial Chemotherapy·C Werckenthin, S Schwarz
Dec 5, 2000·The Journal of Antimicrobial Chemotherapy·J M Hamilton-Miller, S Shah
Dec 5, 2000·The Journal of Antimicrobial Chemotherapy·J M AndrewsR Wise
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·M BoosF J Schmitz
May 25, 2001·Antimicrobial Agents and Chemotherapy·F J SchmitzS Schwarz
Jun 16, 2001·Antimicrobial Agents and Chemotherapy·A M NiliusR K Flamm
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·M J MittenR K Flamm
Sep 28, 2001·Journal of Clinical Microbiology·A C FluitF J Schmitz
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·F J SchmitzS Schwarz
Citations
Jul 5, 2003·International Journal of Antimicrobial Agents·S BesierT A Wichelhaus
Jun 12, 2013·Nature Communications·Pulkit GuptaAlexander S Mankin
Feb 15, 2012·The Journal of Antimicrobial Chemotherapy·Yang WangJianzhong Shen
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Darren AbbanatKaren Bush
Jan 16, 2007·Clinical Microbiology Reviews·Florence DepardieuPatrice Courvalin
Feb 24, 2016·The Journal of Antimicrobial Chemotherapy·Tao HeYang Wang
May 26, 2010·Journal of Applied Microbiology·A M Hammad, T Shimamoto
Dec 24, 2011·Annals of the New York Academy of Sciences·Joyce A Sutcliffe
Mar 11, 2006·International Journal of Medical Microbiology : IJMM·Stefan Schwarz, Corinna Kehrenberg
Jan 28, 2014·Veterinary Microbiology·Monika EntorfStefan Schwarz
May 16, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S G GatermannS Friedrich
Jan 31, 2008·The Journal of Antimicrobial Chemotherapy·Eun-Jeong YoonEung-Chil Choi
Nov 3, 2016·Cold Spring Harbor Perspectives in Medicine·Stefan SchwarzBirte Vester
Aug 12, 2020·The Journal of Antimicrobial Chemotherapy·Valeria BortolaiaFrank M Aarestrup
Feb 21, 2019·BMC Infectious Diseases·Weiming YaoZhijian Yu
Jan 13, 2018·Microbiology Spectrum·Engeline van DuijkerenStefan Schwarz