Molecular characterization of LH-beta and FSH-beta subunits and their regulation by estrogen in the goldfish pituitary

Molecular and Cellular Endocrinology
D L Huggard-NelsonH R Habibi

Abstract

The gonadal steroids, along with gonadotropin-releasing hormone (GnRH) are involved in the regulation of gonadotropin (GtH) production in vertebrates. Goldfish have an annual reproductive cycle, characterized by seasonal fluctuations in the circulating levels of the reproductive hormones, including 17beta-estradiol (E2). The purpose of the present study was to investigate the effect of E2 on basal and GnRH-induced GtH subunit (alpha, FSH-beta and LH-beta) gene expression in the goldfish pituitary. Northern analyses were performed to determine changes in steady state mRNA levels. Both in vivo and in vitro treatment with E2 resulted in a stimulation of all three GtH subunit mRNA levels, although a higher concentration was required for the stimulation of the FSH-beta subunit mRNA levels. The effect of E2 on GnRH-induced GtH mRNA level was also investigated and demonstrated that E2 influences the GnRH-induced GtH subunit mRNA levels in a seasonally dependent manner. Overall, the present results indicate that E2 stimulates GtH subunit mRNA levels directly at the level of the pituitary in a seasonally dependent manner in goldfish.

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Citations

Nov 26, 2013·Fish Physiology and Biochemistry·Borja MuriachJosé Miguel Cerdá-Reverter
Feb 13, 2003·Molecular and Cellular Endocrinology·A VetillardT Bailhache
Nov 22, 2011·General and Comparative Endocrinology·H R HabibiE R O Allan
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Apr 28, 2009·General and Comparative Endocrinology·Yonathan ZoharOlivier Kah
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Apr 30, 2013·Molecular and Cellular Endocrinology·Yun LiuChristopher H K Cheng
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Apr 16, 2013·General and Comparative Endocrinology·Erik R Nelson, Hamid R Habibi
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Dec 15, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Meina XieYuling Mi

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