Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype

The Journal of General Virology
E Susanne JohanssonA Michael Lindberg


Ljungan virus (LV) is a suspected human pathogen recently isolated from bank voles in Sweden. This study describes the genetic characterization of a virus, M1146, which was isolated in 1962 from another vole species (Microtus montanus), trapped in Oregon, USA. Based on antigenic properties, M1146 was postulated previously as a putative member of the family PICORNAVIRIDAE: The near complete genomic sequence verifies that M1146 is a member of the Picornaviridae, most closely related to LVs isolated in Sweden. The strain M1146 possesses typical LV genomic organization, including a cluster of two 2A homologues. There are significant differences throughout the capsid protein region, while the non-structural region of M1146 is closely related to the Swedish LV genomes. Genetic and phylogenetic analyses show that M1146 represents a new genotype within the distinct LV cluster. Isolation of LV from both Swedish and American voles trapped over a period of 30 years suggests a continuous worldwide presence.


Apr 1, 1976·Journal of Wildlife Diseases·A J MainR C Wallis
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Timo HyypiäG Stanway
Jun 1, 1992·Computer Applications in the Biosciences : CABIOS·D T JonesJ M Thornton
Sep 1, 1990·The Journal of General Virology·P Auvinen, Timo Hyypiä
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·E V Koonin, V V Dolja
Aug 1, 1996·The Journal of General Virology·Tuija PöyryG Stanway
Aug 1, 1996·Computer Applications in the Biosciences : CABIOS·R D Page
Jan 1, 1997·The Journal of General Virology·M L DonnellyM D Ryan
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·K Strimmer, A von Haeseler
Nov 20, 1998·The Journal of General Virology·F GhaziG Stanway
Mar 26, 1999·The Journal of General Virology·P MarvilD Cavanagh
Jul 28, 1999·The Journal of General Virology·F M PringleV K Ward
Jun 1, 2000·Molecular Biology and Evolution·S Xu
Feb 13, 2001·The Journal of General Virology·Y KakuY Murakami
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·N Dejucq, B Jégou
Jul 4, 2001·Journal of Virology·H Hahn, A C Palmenberg
Apr 17, 2002·Virus Research·A Michael Lindberg, Susanne Johansson


Jun 6, 2008·Journal of Clinical Microbiology·W Allan NixM Steven Oberste
Oct 19, 2007·Journal of Virology·A KapoorEric Delwart
Mar 12, 2011·Emerging Infectious Diseases·Kirsi S HonkavuoriW Ian Lipkin
May 15, 2013·Archives of Virology·Anne-Marie SalisburyJames P Stewart
May 15, 2012·Journal of Virological Methods·René KalliesMatthias Niedrig
Jul 16, 2013·Journal of Medical Virology·Anne J JääskeläinenOlli Vapalahti
Apr 12, 2008·Journal of Virological Methods·Conny TolfA Michael Lindberg
Feb 13, 2007·Virus Research·Chun-Hsien Tseng, Hsiang-Jung Tsai
Sep 17, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kieran C PounderLorraine M McElhinney
Aug 21, 2008·Journal of Medical Virology·German TapiaKjersti S Rønningen
Oct 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Henry F Krous, Neil E Langlois
Mar 20, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Lili ZhengHong Xin
Feb 4, 2014·Journal of Wildlife Diseases·Claudia RomeoHeidi C Hauffe
Oct 4, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ákos BorosGábor Reuter
May 22, 2016·The Journal of General Virology·Hiromichi MitakeMakoto Sugiyama
Apr 20, 2004·Biochemical and Biophysical Research Communications·E Susanne JohanssonA Michael Lindberg
Feb 14, 2017·Journal of Wildlife Diseases·Cristina FevolaHeidi C Hauffe
Aug 9, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeBo Niklasson
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Nov 7, 2019·Transboundary and Emerging Diseases·Basanta Pravas SahuDebasis Nayak
Jun 4, 2020·Vector Borne and Zoonotic Diseases·Cristina FevolaHeidi C Hauffe

Related Concepts

RNA Conformation
Family Picornaviridae
Determination, Sequence Homology
Viral Nonstructural Proteins NS2
Capsid Proteins

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.