Abstract
The emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa has become a serious worldwide medical problem. This study was designed to clarify the genetic and epidemiological properties of MDR P. aeruginosa strains isolated from hospitals in Myanmar. Forty-five MDR P. aeruginosa isolates obtained from different patients in seven hospitals in Myanmar were screened using the broth microdilution method. The whole genomes of the MDR isolates were sequenced using a MiSeq platform (Illumina). Phylogenetic trees were constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced, and drug resistance genes were identified. Of the 45 isolates, 38 harbored genes encoding carbapenemases, including DIM-1, IMP-1, NDM-1, VIM-2, and VIM-5, and 9 isolates had genes encoding 16S rRNA methylases, including RmtB, RmtD3, RmtE, and RmtF2. Most MDR P. aeruginosa strains isolated in Myanmar belonged to sequence type 1047 (ST1047). This is the first molecular epidemiological analysis of MDR P. aeruginosa clinical isolates in Myanmar. These findings strongly suggest that P. aeruginosa ST1047 strains harboring carbapenemases, including DIM-, IMP-, NDM-, and VIM-type metallo-β-lactamases, have been spreading thr...Continue Reading
References
Oct 23, 1997·Antimicrobial Agents and Chemotherapy·M NakanoY Kawada
Oct 31, 2000·Applied and Environmental Microbiology·M T SuzukiE F DeLong
Mar 27, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K Bush
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Jun-Ichi WachinoYoshichika Arakawa
Nov 11, 2009·Antimicrobial Agents and Chemotherapy·Marta TatoRafael Cantón
Jan 15, 2010·The Journal of Antimicrobial Chemotherapy·Carlos JuanAntonio Oliver
Jun 9, 2010·Systematic Biology·Stéphane GuindonOlivier Gascuel
Nov 16, 2010·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Po-Ren HsuehLee-Jene Teng
May 3, 2011·The Lancet Infectious Diseases·Giuseppe CornagliaGian Maria Rossolini
May 2, 2012·Antimicrobial Agents and Chemotherapy·Marc GalimandThierry Lambert
Jun 8, 2012·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jun-ichi Wachino, Yoshichika Arakawa
Mar 6, 2013·Antimicrobial Agents and Chemotherapy·Maria Fernanda C BuenoYohei Doi
Mar 13, 2013·Antimicrobial Agents and Chemotherapy·Jessica A O'HaraYohei Doi
Jul 10, 2013·Antimicrobial Agents and Chemotherapy·Tatsuya TadaTeruo Kirikae
Jul 12, 2013·The Journal of Antimicrobial Chemotherapy·Moon Jung KimKyungwon Lee
Aug 6, 2014·Antimicrobial Agents and Chemotherapy·Tatsuya TadaBharat M Pokhrel
Jul 15, 2015·Infection & chemotherapy·Duck Jin HongKyungwon Lee
Aug 26, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Antonio OliverCarlos Juan
Jun 27, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P TreepongD Hocquet
Mar 27, 2018·Veterinary Dermatology·Jae-Eun HyunCheol-Yong Hwang
Dec 12, 2018·Microbiology Resource Announcements·George TaiaroaAdam Heikal
Citations
Jun 19, 2019·The Journal of Antimicrobial Chemotherapy·P UrbanowiczM Gniadkowski
Feb 27, 2020·Journal of Medical Microbiology·Shovita ShresthaJeevan B Sherchand
Nov 14, 2019·MBio·Andreu Coello PelegrinJuliëtte A Severin
Dec 18, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jun Sung HongSeok Hoon Jeong
Jan 15, 2021·BMJ Open Respiratory Research·Iwein GyselinckRobin Vos
Feb 19, 2021·Pharmacological Reviews·Mariana Angoa-Pérez, Donald M Kuhn
Mar 9, 2021·Frontiers in Microbiology·Eun-Jeong Yoon, Seok Hoon Jeong
Oct 5, 2020·Infectious Disease Clinics of North America·Jun-Ichi WachinoYoshichika Arakawa
Sep 28, 2020·Diagnostic Microbiology and Infectious Disease·Zuhal Kalaycı ÇekinElif Aktaş
Jun 29, 2021·The Journal of Antimicrobial Chemotherapy·P UrbanowiczM Gniadkowski
Jul 13, 2021·Frontiers in Microbiology·Xuemeng JiShuo Wang
Jul 21, 2021·Journal of Global Antimicrobial Resistance·Toshihiro TakahashiJeevan B Sherchand