Molecular characterization of newly recognized rodent parvoviruses

The Journal of General Virology
David G BesselsenLela K Riley

Abstract

Several autonomous rodent parvoviruses distinct from the prototypic rodent parvoviruses have been isolated. These include variants of a mouse parvovirus (MPV), a hamster isolate designated hamster parvovirus (HaPV), and a variant strain of minute virus of mice (MVM) designated MVM-Cutter or MVM(c). In this study, the DNA sequence of the coding regions of the viral genome and the predicted protein sequences for each of these new isolates were determined and compared to the immunosuppressive and prototypic strains of MVM [MVM(i) and MVM(p)], the rodent parvovirus H-1, and LuIII, an autonomous parvovirus of uncertain host origin. Sequence comparisons showed that the MPV isolates were almost identical, HaPV was very similar to MPV, and MVM(c) was most similar to MVM(i) and MVM(p). Haemagglutination inhibition assays revealed that MPV and HaPV represent two serotypes distinct from previously characterized rodent parvovirus serotypes while MVM(c) belongs to the MVM serotype. Each of the newly isolated rodent parvoviruses was shown to encapsidate a predominantly negative-sense 5 kb DNA genome and to encode two nonstructural proteins (NS1 and NS2) and two structural viral proteins (VP1 and VP2). These studies indicate that MPV and HaPV...Continue Reading

Citations

May 29, 2008·ILAR Journal·David G BesselsenLela K Riley
Apr 3, 2013·Experimental and Molecular Pathology·Joongho JohShin-Je Ghim
Aug 31, 2001·ILAR Journal·Steven H. WeisbrothWilliam Shek
Mar 21, 2001·The Journal of General Virology·M Söderlund-VenermoD J Pintel
Jul 19, 2002·The Journal of General Virology·Cho-Hua WanLela K Riley
Dec 9, 2004·The Veterinary Clinics of North America. Exotic Animal Practice·Corinna KashubaCraig Franklin
Nov 1, 2011·Laboratory Animals·Lydia M Janus, Andre Bleich
Nov 17, 1998·Experimental Animals·Y UenoK Yagami
Mar 9, 2018·The Journal of General Virology·Rachel D BrownleeDavid G Besselsen
Apr 1, 1997·The Journal of Veterinary Medical Science·Y UenoK Yagami
Jul 15, 2003·Journal of Virology·José C SegoviaJuan A Bueren
Apr 29, 2020·Nature Biotechnology·Paul W BaroneStacy L Springs
May 13, 2006·The Journal of General Virology·David G BesselsenRobert S Livingston
Apr 30, 2021·Biotechnology and Bioengineering·Joleen SuDayue Chen

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