Molecular characterization of penile cancer : Literature review of new prognostic markers and potential therapeutic targets

Der Urologe. Ausg. A
M MayM Burger

Abstract

Squamous cell carcinoma of the penis (SCCP) is a rare cancer type in Western industrialized nations; nevertheless, it shows an aggressive course of disease in advanced tumor stages with accordantly high recurrence and progression rates. While molecular biomarkers are not established in clinical routine for the management of SCCP patients yet, the accordant unmet need is enormous, as adequate biomarkers would be meaningful for prognostic determination, planning of modality and extent of primary therapy, indication for inguinal lymph node resection, adjuvant treatment, and as potential targets for specific systemic treatment. SCCP regularly develops from a precursor lesion. In this regard, human papillomavirus (HPV)-dependent and -independent pathways are differentiated. The potential for specific target therapy options is mainly based on the decoding of genetic and epigenetic signatures of distinct molecular pathways. In order to develop targeted and personalized treatment strategies based on molecular pathways, an increase in translational research in large multi-institutional collaborations must be promoted. This review article aims to summarize the current status of research concerning molecular changes related to SCCP under ...Continue Reading

References

Apr 3, 2001·Genes, Chromosomes & Cancer·G AlvesT Liehr
Dec 18, 2001·The Journal of Urology·Antonio C P MartinsSilvio Tucci
Jun 21, 2005·BJU International·Navid BerdjisManfred P Wirth
Nov 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Oliver J KayesGareth H Williams
Nov 19, 2010·Virchows Archiv : an International Journal of Pathology·Micaela PoetschChris Protzel
Dec 3, 2011·Journal of Clinical Pathology·Sven GuniaMatthias May
Mar 27, 2012·Journal of Clinical Pathology·Elzbieta StankiewiczDaniel M Berney
Sep 25, 2012·The Journal of Urology·Emili MasferrerAgustí Toll
Dec 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R H A VerhoevenUNKNOWN EUNICE Survival Working Group
May 25, 2013·International Journal of Molecular Sciences·Hellen KuasneIlce Mara de Syllos Cólus
Jul 4, 2013·Journal of Translational Medicine·Giuseppe Di LorenzoRenato Franco
Dec 3, 2014·European Urology·Oliver W HakenbergNick Watkin
Dec 17, 2014·Expert Opinion on Biological Therapy·Giuseppe Di LorenzoMichele Aieta
Dec 17, 2014·Cancer Prevention Research·Ariane F Busso-LopesSilvia R Rogatto
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew FeberJohn D Kelly
Nov 29, 2015·The Urologic Clinics of North America·Camille VuichoudKevin R Loughlin
May 25, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M UdagerR Mehra
Oct 5, 2016·The Journal of Urology·Sarah R OttenhofEkaterina S Jordanova
Aug 17, 2017·International Journal of Molecular Sciences·Juan ChipolliniPhilippe E Spiess
Dec 14, 2017·Aktuelle Urologie·M RoinerO W Hakenberg
Feb 23, 2018·Der Urologe. Ausg. A·A AzizO W Hakenberg
Feb 28, 2018·Der Urologe. Ausg. A·P Schneede, B Schlenker

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Citations

Nov 5, 2020·World Journal of Urology·Joren VanthoorMaarten Albersen

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