Molecular characterization, structure and developmental expression of Megane bHLH factor

Gene
J GuimeraWolfgang Wurst

Abstract

We report here the full-length sequence identification, molecular characterization, detailed demarcation expression analysis relevant to morphological marker genes and mapping of a bHLH transcription gene, referred to as Megane (Mgn). Mgn protein is structurally related to the neurogenic Drosophila hairy and Enhancer of split (h/E(spl)) proteins. The unique structural properties of Mgn factor in several characteristic residues define the gene as related to h/E(spl), but distinguish it from previously identified mammalian members of the family. Mgn is a single copy gene on mouse chromosome 8 and encodes a 27kDa protein that functions in the nucleus. First expression of Mgn is detected at mouse embryonic day 9.5 within the most rostral part of the cephalic flexure of the developing midbrain. Later, Mgn expression extends into other alar areas of the midbrain and forebrain, developmentally controlled in a regional specific pattern.

References

Feb 1, 1997·Current Opinion in Neurobiology·J E Lee
Dec 6, 1997·Current Opinion in Genetics & Development·R Kageyama, S Nakanishi
Jun 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Fisher, M Caudy
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·A W MooreY N Jan
Jul 3, 2002·Nature Reviews. Neuroscience·Nicolas BertrandFrançois Guillemot
Jul 10, 2003·Neuron·Sarah E RossCharles D Stiles
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Goichi MiyoshiRyoichiro Kageyama
Aug 24, 2004·Cell and Tissue Research·Nilima Prakash, Wolfgang Wurst

❮ Previous
Next ❯

Citations

Nov 25, 2011·Molecular Biology and Evolution·Joshua K SailsberyRalph A Dean
Nov 8, 2013·Cellular and Molecular Life Sciences : CMLS·Kaia AchimJuha Partanen
Jul 27, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L Gimeno, S Martinez
Apr 27, 2010·Developmental Biology·Paula PeltopuroJuha Partanen
Nov 5, 2014·Biomolecular Concepts·Suyan LiAnju Vasudevan
Apr 1, 2011·The Journal of Comparative Neurology·Prisca ChapoutonLaure Bally-Cuif

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.