Molecular classification and clonal differentiation of hepatocellular carcinoma: the step forward for patient selection for liver transplantation

Expert Review of Gastroenterology & Hepatology
Ricardo GehrauDaniel G Maluf

Abstract

Liver transplantation is a successful treatment for hepatocellular carcinoma (HCC). However, advanced stages are not selected for transplant, based on the United Network for Organ Sharing selection criteria's. Nowadays, molecular biology-based techniques constitute an excellent option to better understand HCC origin differentiation and biological behavior. Moreover, microarray technology is a powerful tool to address a variety of tumor tissues at molecular level and is actively used for the discovery of biomarkers in cancer research. This article will discuss published data in the field of HCC origin differentiation and its potential impact on outcomes following liver transplantation. Although preliminary results are presented, these findings encourage the use of gene-expression profiling microarrays for studying HCC biology and behavior and ultimately optimizing treatment success.

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Citations

Feb 1, 2013·Expert Review of Gastroenterology & Hepatology·Ricardo C GehrauDaniel G Maluf
Aug 1, 2012·Seminars in Oncology·Emmanuel MelloulPierre-Alain Clavien
Apr 30, 2015·Journal of Vascular and Interventional Radiology : JVIR·Daniel G Maluf, Valeria R Mas
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Nov 27, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Han WangWen-Ming Cong
May 23, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Lei WangJingfeng Liu
Dec 25, 2012·Fibrogenesis & Tissue Repair·Ricardo GehrauDaniel Maluf

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