Molecular classification of adult gliomas: recent advances and future perspectives

Current Opinion in Oncology
Marc BarritaultFrançois Ducray

Abstract

This review summarizes recent advances in the molecular classification of adult gliomas. According to the 2016 WHO classification, five main molecular subgroups of adult diffuse gliomas can be distinguished based on the 1p/19q codeletion, isocitrate dehydrogenase (IDH), and histone H3.3 mutation status. In the future, this classification may be further refined based on the integration of additional biomarkers, in particular CDKN2A/B homozygous deletion in IDH-mutant astrocytomas, TERT promoter mutations, EGFR amplification, chromosome 7 gain and chromosome 10 loss in IDH-wildtype astrocytomas, and FGFR1 mutations in midline gliomas. Histone H3.3 G34R/V defines a distinct subgroup of hemispheric IDH-wildtype high-grade gliomas occurring in young patients and FGFR gene fusions characterize a subgroup of IDH-wildtype glioblastomas that could benefit from specific treatment approaches. RNA sequencing may identify targetable gene fusions in circumscribed gliomas lacking classical BRAF alterations. In chordoid gliomas, recurrent PRKCA mutations could serve as a new diagnostic marker. Among comprehensive molecular analysis methods, DNA methylation profiling appears as a particularly powerful approach to identify new molecular subgroup...Continue Reading

References

Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J van den BentKhê Hoang-Xuan
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory CairncrossMinesh Mehta
Apr 8, 2015·Nature Genetics·Hiromichi SuzukiSeishi Ogawa
May 29, 2015·Annals of Neurology·Vincent GleizeMarc Sanson
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Jun 13, 2015·Nature Communications·Karim LabrecheUNKNOWN POLA Network
Jun 20, 2015·Acta Neuropathologica·David E ReussAndreas von Deimling
Sep 20, 2015·Neurology·Agustí AlentornUNKNOWN POLA Network
Dec 25, 2015·Nature·William A FlavahanBradley E Bernstein
Mar 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric BouffetUri Tabori
Apr 7, 2016·The New England Journal of Medicine·Jan C BucknerWalter J Curran
Aug 31, 2016·Acta Neuropathologica·Emeline TabouretUNKNOWN For POLA Network
Sep 15, 2016·Nature Communications·Mélissa CarbonneauFrédérick A Mallette
Jan 27, 2017·Acta Neuropathologica·Stefan PuschAndreas von Deimling
Feb 16, 2017·Neuro-oncology·David MeyronetFrançois Ducray
Feb 27, 2017·Neurology·Denis MiglioriniPierre-Yves Dietrich
Mar 16, 2017·The New England Journal of Medicine·James R PerryUNKNOWN Trial Investigators
Mar 17, 2017·Cold Spring Harbor Molecular Case Studies·Susan J HsiaoJames H Garvin
Apr 19, 2017·Acta Neuropathologica Communications·Tina Y HuangAmanda M Saratsis
May 10, 2017·The Lancet Oncology·Michael WellerUNKNOWN European Association for Neuro-Oncology (EANO) Task Force on Gliomas
Jun 3, 2017·Neuro-oncology·Abudumijit AibaidulaHo-Keung Ng

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Citations

Oct 31, 2021·International Journal of Experimental Pathology·Adrian Tira, Lela Buckingham
Aug 6, 2021·The American Journal of Surgical Pathology·Leiming WangLianghong Teng

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