Molecular classification of bladder cancer. Possible similarities to breast cancer

Der Pathologe
Ralph M WirtzA Hartmann

Abstract

Therapeutic decisions for breast cancer are increasingly becoming based on subtype-specific gene expression tests. For bladder cancer very similar subtypes have been identified by genome-wide mRNA analysis, which as for breast cancer differ with respect to the prognosis and response to therapy on the basis of their hormone dependency. At the DNA level, however, the type of mutations and their frequencies within the subtypes are strikingly different between bladder and breast cancers. It will be interesting to see whether possible driver mutations can serve as therapeutic targets in both indications. In contrast, the apparent hormone dependency of a substantial number of bladder carcinomas suggests that hormonal and anti-hormonal treatment can be valid therapy options similar to breast cancer. Moreover, gender-specific differences with respect to the incidence and aggressiveness of male compared to female bladder cancers can be explained by hormonal effects. Together with forthcoming immunomodulatory therapies these multiple therapy options raise and give new hope to efficiently combat this aggressive disease.

References

Aug 30, 2000·Nature·C M PerouD Botstein
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Therese Sørlie
Jul 3, 2008·Cancer Research·Marcus SchmidtMathias Gehrmann
Feb 21, 2009·The New England Journal of Medicine·Christos Sotiriou, Lajos Pusztai
Mar 26, 2009·Cancer Research·Marcus SchmidtMathias C Gehrmann
Jul 2, 2009·Cancer Causes & Control : CCC·An-Tsun HuangKenneth P Cantor
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carsten DenkertGunter von Minckwitz
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sherene LoiChristos Sotiriou
Apr 2, 2011·European Urology·Arnulf StenzlUNKNOWN European Association of Urology (EAU)
Apr 5, 2011·European Urology·Marko BabjukUNKNOWN European Association of Urology (EAU)
Apr 16, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carol A Davis-DaoVictoria K Cortessis
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Dec 20, 2011·The Journal of Urology·Bas W G van Rhijn
Aug 11, 2012·European Urology·Maximilian BurgerYair Lotan
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Nov 8, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C DenkertG von Minckwitz
Jun 5, 2013·Translational Oncology·Suraj Konnath GeorgeCarolyn L Smith
Jan 31, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey S DamrauerWilliam Y Kim
Dec 24, 2014·Nature Reviews. Cancer·Margaret A Knowles, Carolyn D Hurst
Mar 17, 2015·European Urology·Oliver PatschanMattias Höglund

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.