Molecular classification of cancers of unknown primary site.

Molecular Diagnosis & Therapy
F Anthony Greco, Mark G Erlander

Abstract

Cancer of unknown primary site is a common metastatic cancer, diagnosed in about 50 000 patients per year in the US. The diagnosis, classification, and management of patients with carcinoma of unknown primary site has been difficult and frustrating. The therapy has usually been empiric for the majority of patients, and their prognosis has been poor. Molecular classification of metastatic cancers with known primary sites has been accurate (76-89%), as reported from several studies. Molecular profiling of initial biopsy specimens has tremendous potential as a test to diagnose the site of tumor origin in patients with unknown primary cancer. Several retrospective studies of molecular profiling assays have provided indirect validation of the accuracy of primary site prediction, based on correlations with clinicopathologic features. One additional study of initial diagnostic biopsies in unknown primary cancer patients, where primary tumor sites were identified months to years later, has provided more direct validation of the accuracy of molecular classification (the primary tumor sites of 15 of 20 patients were correctly predicted). The ability to diagnose and classify unknown primary cancer more precisely would allow for more site-...Continue Reading

References

Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·S RamaswamyT R Golub
Dec 26, 2003·The American Journal of Pathology·Greg BloomTimothy J Yeatman
Apr 6, 2006·Archives of Pathology & Laboratory Medicine·Xiao-Jun MaMark Erlander
Jul 11, 2006·The Journal of Molecular Diagnostics : JMD·Dimitri TalantovAbhijit Mazumder
May 2, 2007·The Oncologist·George PentheroudakisNicholas Pavlidis
Jun 23, 2007·Nature Reviews. Cancer·Christos Sotiriou, Martine J Piccart
Aug 19, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·George PentheroudakisNicholas Pavlidis
Mar 26, 2008·Nature Biotechnology·Nitzan RosenfeldIris Barshack
Apr 17, 2008·British Journal of Cancer·J BridgewaterL Van'T Veer
May 31, 2008·The Lancet Oncology·Gauri R VaradhacharyJames L Abbruzzese
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hugo M HorlingsDaphne de Jong
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gauri R VaradhacharyJohn D Hainsworth
Jan 31, 2009·Seminars in Oncology·Karin A Oien
Jan 31, 2009·Seminars in Oncology·Richard A Bender, Mark G Erlander
Jan 31, 2009·Seminars in Oncology·John D Hainsworth, Karim Fizazi
Apr 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico A MonzonGlenda G Anderson
Jun 19, 2009·International Journal of Cancer. Journal International Du Cancer·Ryan K van LaarAnnuska M Glas

❮ Previous
Next ❯

Citations

Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Aurelio ArizaEmilio Alba
May 30, 2013·American Society of Clinical Oncology Educational Book·F Anthony Greco
Jan 28, 2014·Der Radiologe·A StenzingerW Weichert
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Catherine A Schnabel, Mark G Erlander
May 4, 2013·Journal of the National Cancer Institute·F Anthony GrecoJohn D Hainsworth
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F A GrecoH Wasan
Mar 5, 2011·Biochimica Et Biophysica Acta·C NatoliS Iacobelli
Jun 29, 2011·The Journal of Molecular Diagnostics : JMD·Mark G ErlanderCatherine A Schnabel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Thrombosis and Hemostasis
Raffaele PesaventoPaolo Prandoni
The British Journal of Psychiatry : the Journal of Mental Science
J I EscobarW Compton
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
S Madani, J Shapiro
© 2022 Meta ULC. All rights reserved