PMID: 11911124Mar 26, 2002Paper

Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling

The Pharmacogenomics Journal
J L OestreicherW L Trepicchio

Abstract

Psoriasis is recognized as the most common T cell-mediated inflammatory disease in humans. Genetic linkage to as many as six distinct disease loci has been established but the molecular etiology and genetics remain unknown. To begin to identify psoriasis disease-related genes and construct in vivo pathways of the inflammatory process, a genome-wide expression screen of multiple psoriasis patients was undertaken. A comprehensive list of 159 genes that define psoriasis in molecular terms was generated; numerous genes in this set mapped to six different disease-associated loci. To further interpret the functional role of this gene set in the disease process, a longitudinal pharmacogenomic study was initiated to understand how expression levels of these transcripts are altered following patient treatment with therapeutic agents that antagonize calcineurin or NF-KB pathways. Transcript levels for a subset of these 159 genes changed significantly in those patients who responded to therapy and many of the changes preceded clinical improvement. The disease-related gene map provides new insights into the pathogenesis of psoriasis, wound healing and cellular-immune reactions occurring in human skin as well as other T cell-mediated autoim...Continue Reading

References

Jan 1, 1994·Archives of Dermatological Research·L KowalzickJ Ring
Mar 2, 1995·The New England Journal of Medicine·M W Greaves, G D Weinstein
Feb 1, 1997·The Journal of Investigative Dermatology·M V RivasJ G Krueger
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R A HellerR W Davis
Sep 1, 1997·Nature Genetics·H P Erickson
Sep 1, 1997·Nature Genetics·G H BurchJ Bristow
Apr 16, 1998·The Journal of Investigative Dermatology·F van RuissenJ Schalkwijk
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·K G BeckerJ M Trent
Sep 15, 1998·Human Molecular Genetics·J Bhalerao, A M Bowcock
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·S J HughesS Hanash
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·P TamayoT R Golub
Sep 18, 1999·Archives of Dermatology·B J Nickoloff
Sep 28, 1999·Molecular Medicine Today·E Herlaar, Z Brown
Dec 10, 1999·The Journal of Clinical Investigation·W L TrepicchioJ G Krueger
May 10, 2000·American Journal of Human Genetics·R P NairJ T Elder
Jul 6, 2000·Immunopharmacology·S Matsuda, S Koyasu
Oct 29, 2000·Science·A A HillE L Brown

❮ Previous
Next ❯

Citations

Jan 28, 2005·Journal of Biochemical and Molecular Toxicology·James V RogersCarol L K Sabourin
Jan 28, 2005·Journal of Biochemical and Molecular Toxicology·Carol L K SabourinJohn J Schlager
Nov 12, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jerzy K KulskiHidetoshi Inoko
Jun 6, 2009·Archives of Dermatological Research·Anthony KarpouzisStavroula Vouliana Veletza
Aug 2, 2003·Journal of the American Academy of Dermatology·Anne M Bowcock, Jonathan N Barker
Jul 23, 2002·Current Opinion in Chemical Biology·Joanne M Meyer, Geoffrey S Ginsburg
Dec 17, 2009·Expert Reviews in Molecular Medicine·Emoke Rácz, Errol P Prens
May 5, 2009·Nature Reviews. Rheumatology·Jason W BauerEmily C Baechler
Jan 7, 2004·The Journal of Experimental Medicine·Edmund LeeJames G Krueger
Oct 31, 2006·Omics : a Journal of Integrative Biology·Miroslav Blumenberg
Oct 6, 2007·Current Opinion in Rheumatology·Sarah A PendergrassHumphrey Gardner
Jan 23, 2003·Annals of the New York Academy of Sciences·Luc AujameMarissa Vicari
Mar 3, 2010·Annual Review of Immunology·Virginia PascualJacques Banchereau
Nov 4, 2009·Mediators of Inflammation·Manfred Kunz, Saleh M Ibrahim
Oct 5, 2010·Mediators of Inflammation·Daniela BraconiAnnalisa Santucci
Aug 24, 2013·BioMed Research International·Nevena SkrozaConcetta Potenza
Jun 17, 2004·The Journal of Clinical Investigation·Brian J Nickoloff, Frank O Nestle
Sep 14, 2012·BMC Genomics·Chrysanthi AinaliSophia Tsoka
Apr 10, 2010·BMC Systems Biology·Eleonora PiruzianTatiana Nikolskaya
Jan 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Francesca ChamianJames G Krueger
Sep 26, 2013·Journal of Proteomics·James C WilliamsonOle N Jensen
Nov 22, 2014·Dermatologic Clinics·Amy C Foulkes, Richard B Warren
Aug 9, 2003·Expert Opinion on Drug Safety·Jeffrey A Kramer, Kyle L Kolaja
Apr 4, 2012·Expert Opinion on Drug Discovery·Lars SvenssonHanne Norsgaard
Nov 7, 2008·Cutaneous and Ocular Toxicology·James V RogersJohn S Graham
Jun 15, 2011·Human Pathology·Kriangsak RuchusatsawatApiwat Mutirangura
Mar 18, 2011·The Journal of Investigative Dermatology·Emoke RáczLeslie van der Fits
Dec 16, 2005·The Journal of Investigative Dermatology·Gys J de JonghJoost Schalkwijk
Jun 4, 2004·The Journal of Investigative Dermatology·Lena SamuelssonJan Wahlström
Jul 20, 2007·The Journal of Investigative Dermatology·Malgorzata RomanowskaJohn Foerster
Oct 12, 2007·The Journal of Investigative Dermatology·Asifa S HaiderJames G Krueger
Nov 11, 2011·The Journal of Investigative Dermatology·Elisha D O RobersonAnne M Bowcock
Mar 12, 2010·The Journal of Investigative Dermatology·Johann E GudjonssonJames T Elder
Jul 6, 2012·The Journal of Investigative Dermatology·Mayte Suárez-FariñasJames G Krueger
Apr 29, 2006·The Journal of Investigative Dermatology·Frank WangJames G Krueger
Jul 22, 2006·The Journal of Investigative Dermatology·Joachim ReischlJürgen F Heubach
Jun 3, 2006·The Journal of Investigative Dermatology·Nicholas R BensonGerald G Krueger
Jan 19, 2005·The Journal of Investigative Dermatology·Lina M CarlénMona Ståhle
May 20, 2008·Seminars in Cutaneous Medicine and Surgery·Manfred Kunz
Apr 18, 2007·Journal of the American Academy of Dermatology·Kenneth Y Tsai, Hensin Tsao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.