Molecular clocks and the human condition: approaching their characterization in human physiology and disease

Diabetes, Obesity & Metabolism
Garret A FitzGeraldC Skarke

Abstract

Molecular clockworks knit together diverse biological networks and compelling evidence from model systems infers their importance in metabolism, immunological and cardiovascular function. Despite this and the diurnal variation in many aspects of human physiology and the phenotypic expression of disease, our understanding of the role and importance of clock function and dysfunction in humans is modest. There are tantalizing hints of connection across the translational divide and some correlative evidence of gene variation and human disease but most of what we know derives from forced desynchrony protocols in controlled environments. We now have the ability to monitor quantitatively ex vivo or in vivo the genome, metabolome, proteome and microbiome of humans in the wild. Combining this capability, with the power of mobile telephony and the evolution of remote sensing, affords a new opportunity for deep phenotyping, including the characterization of diurnal behaviour and the assessment of the impact of the clock on approved drug function.

References

Jan 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·F HALBERGJ J BITTNER
Oct 19, 2005·Circulation·R Daniel RudicGarret A FitzGerald
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anne M CurtisGarret A Fitzgerald
Jul 27, 2007·The New England Journal of Medicine·Nicholas A Christakis, James H Fowler
Apr 17, 2008·Circulation·Elizabeth J WestgateGarret A FitzGerald
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Katja A LamiaCharles J Weitz
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Georgios K PaschosGarret A FitzGerald
Oct 4, 2011·Vascular Health and Risk Management·Ehud GrossmanNava Zisapel
Aug 21, 2012·Biochemical and Biophysical Research Communications·Makiko WatanabeKazuo Mishima
Nov 13, 2012·Nature Medicine·Georgios K PaschosGarret A Fitzgerald
Nov 21, 2013·Cancer Research·Hiroyuki OkazakiShigehiro Ohdo
Nov 22, 2013·Science Translational Medicine·Guangrui YangGarret A FitzGerald
Nov 26, 2013·The Journal of Clinical Investigation·Erik S MusiekGarret A Fitzgerald
Jun 4, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·F WangL A Tse
Jul 17, 2014·Journal of Developmental Origins of Health and Disease·C CooperJ Eriksson
Sep 23, 2014·Aging·Rohini V KhapreRoman V Kondratov
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ray ZhangJohn B Hogenesch
Dec 30, 2014·PloS One·Pablo Martinez-Lozano SinuesRobert Dallmann
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aalim M WeljieAmita Sehgal
Mar 15, 2015·Science·Shubhroz GillSatchidananda Panda
May 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anne M CurtisLuke A J O'Neill

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Citations

Dec 8, 2017·Scientific Reports·Carsten SkarkeGarret A FitzGerald
Mar 17, 2019·EMBO Reports·Samuel Philip NobsEran Elinav
Apr 24, 2020·Circulation Research·Calum A MacRae, Robert M Califf
Feb 14, 2020·Chronobiology International·Victor Schmalle, Axel Lorentz

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