PMID: 8962122Dec 10, 1996Paper

Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin

Proceedings of the National Academy of Sciences of the United States of America
T NagasawaT Kishimoto

Abstract

Pre-B-cell growth-stimulating factor/ stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor and as a pre-B-cell stimulatory factor. Although most chemokines are thought to be inducible inflammatory mediators, PBSF/SDF-1 is essential for perinatal viability,. B lymphopoiesis, bone marrow myelopoiesis, and cardiac ventricular septal formation, and it has chemotactic activities on resting lymphocytes and monocytes. In this paper, we have isolated a cDNA that encodes a seven transmembrane-spanning-domain receptor, designated pre-B-cell-derived chemokine receptor (PB-CKR) from a murine pre-B-cell clone, DW34. The deduced amino acid sequence has 90% identity with that of a HUMSTSR/fusin, a human immunodeficiency virus 1 (HIV-1) entry coreceptor. However, the second extracellular region has lower identity (67%) compared with HUMSTSR/fusin. PB-CKR is expressed during embryo genesis and in many organs and T cells of adult mice. Murine PBSF/SDF-1 induced an increase in intracellular free Ca2+ in DW34 cells and PB-CKR-transfected Chinese hamster ovary (CHO) cells, suggesting that PB-CKR is a functional receptor for murine PBSF/SDF-1. ...Continue Reading

References

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Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·T NagasawaT Kishimoto
Sep 1, 1996·The Journal of Experimental Medicine·C C BleulT A Springer

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Citations

Feb 18, 2011·Annals of Hematology·Mohammad R IrhimehRobert E Nordon
Feb 15, 2012·Brain Tumor Pathology·Shintaro FukushimaKoichi Ohshima
Sep 29, 2006·Cancer Metastasis Reviews·Gera Neufeld, Ofra Kessler
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Aug 18, 2000·The European Journal of Neuroscience·C LimatolaF Eusebi
Jun 28, 2012·The Journal of Biological Chemistry·Frauke HoffmannRalf Stumm
May 2, 2008·The Journal of Biological Chemistry·Aasia O Rehman, Cun-Yu Wang
Mar 27, 2010·International Immunology·Atsushi Kumanogoh, Masato Ogata
Feb 8, 2007·Journal of the National Cancer Institute·Takayuki NakayamaGiovanna Tosato
May 12, 2000·Critical Care Medicine·M P Keane, R M Strieter
Apr 1, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hideo Ema, Hiromitsu Nakauchi
Jan 5, 2005·The Journal of Clinical Investigation·Isabelle PetitTsvee Lapidot
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