PMID: 19940393Nov 27, 2009Paper

Molecular cloning and expression analysis of bat toll-like receptors 3, 7 and 9

The Journal of Veterinary Medical Science
Koichiro IhaYasuhiro Yoshikawa

Abstract

In this study, cDNA of Toll-like receptors (TLR) 3, 7 and 9 were synthesized and completely sequenced. The coding regions of cDNA for bat TLR3, TLR7 and TLR9 were 2,718, 3,150 and 3,090 bp in length, respectively. The open reading frames encoded 905, 1,049 and 1,029 amino acids for TLR3, TLR7 and TLR9, respectively. The nucleotide sequences, predicted amino acid sequences and predicted domain structures of the three bat TLRs had high homology with those of other mammals. In addition, the expression profiles of each TLR in main organs were analyzed. Expression of TLR3 was highest in the liver, whereas the expressions of TLR7 and TLR9 were highest in the spleen.

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Citations

Jun 19, 2013·Trends in Microbiology·Jasper Fuk-Woo ChanKwok-Yung Yuen
Aug 10, 2010·Developmental and Comparative Immunology·Christopher CowledLin-Fa Wang
Jan 11, 2013·Zoonoses and Public Health·M L BakerL-F Wang
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Nov 25, 2011·Gastroenterology Research and Practice·A G Miranda-DíazL M Román-Pintos
Dec 15, 2011·Developmental and Comparative Immunology·Christopher CowledLin-Fa Wang
Jan 13, 2015·Trends in Microbiology·Cara E Brook, Andrew P Dobson
May 21, 2020·Annual Review of Virology·Emilia C SkirmunttAris Katzourakis
Dec 26, 2016·Immunogenetics·Haiying JiangJinping Chen

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