Abstract
Previously, it has been shown that glycoproteins with approximately 130-kDa molecular mass react with antisera from patients with renal vasculitis (Kain, R., Matsui, K., Exner, M., Binder, S., Schaffner, G., Sommer, E. M., and Kerjaschki, D. (1995) J. Exp. Med. 181, 585-597). To search for a molecule that reacts with the antibodies, we screened a lambdagt11 human placental cDNA library. Two of the isolated clones were found to encode a putative counterpart of the rodent trans-Golgi network (TGN) glycoprotein 38, hTGN46, which has the tyrosine containing motif YQRL shared by mouse and rat TGN38. Moreover, reverse transcription-polymerase chain reaction analysis of hTGN46 transcripts and genomic analysis of a cDNA deposited as an expressed sequence tag in dbEST Data Base revealed that additional cDNAs exist that are produced by alternate usage of 3'-splice sites of intron III. Alternative splicing results in frame shifts and leads to novel larger translation products with one (for hTGN48) or two (for hTGN51) additional tyrosine-containing motifs. hTGN51 expressed in Chinese hamster ovary cells were localized to the trans-Golgi network, overlapping with beta-1,4-galactosyltransferase even after mutating the tyrosine-containing mot...Continue Reading
References
Jun 26, 1992·Cell·F Letourneur, R D Klausner
Apr 1, 1992·The Journal of Cell Biology·C Harter, I Mellman
Apr 15, 1992·The Biochemical Journal·B ReavesG Banting
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D AokiM N Fukuda
Aug 15, 1990·The Biochemical Journal·J P LuzioK K Stanley
Sep 1, 1990·The Journal of Cell Biology·M A Williams, M Fukuda
Jun 2, 1989·Cell·P LobelS Kornfeld
Oct 5, 1987·Biochimica Et Biophysica Acta·J Roth
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P D Siebert, M Fukuda
Jan 1, 1985·Annual Review of Cell Biology·M G Farquhar
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Jun 16, 1995·The Journal of Biological Chemistry·K KasaiK Nakayama
Sep 29, 1995·Science·H OhnoJ S Bonifacino
Jul 4, 1995·Gene·M Onda, M Fukuda
Aug 25, 1995·The Journal of Biological Chemistry·L PondP A Peterson
May 15, 1995·Genes & Development·M N FukudaS Nozawa
Feb 1, 1995·The Journal of Experimental Medicine·R KainD Kerjaschki
Jan 1, 1994·Sub-cellular Biochemistry·M Fukuda
Apr 1, 1994·The Journal of Cell Biology·S PonnambalamG Warren
Jan 1, 1993·Annual Review of Cell Biology·I S TrowbridgeC R Hopkins
Aug 1, 1993·The Journal of Cell Biology·S M JonesK E Howell
Mar 1, 1993·The Journal of Cell Biology·J S HumphreyJ S Bonifacino
Jan 26, 1996·The Journal of Biological Chemistry·F MauxionB Hoflack
Oct 1, 1996·The Journal of Cell Biology·M S MarksJ S Bonifacino
Mar 14, 1997·The Journal of Biological Chemistry·K AngataM Fukuda
Jun 2, 1997·The Journal of Cell Biology·N R Gough, D M Fambrough
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Aug 1, 1997·Current Opinion in Cell Biology·L M Traub, S Kornfeld
Sep 5, 1997·The Journal of Biological Chemistry·D SkrincoskyM Fukuda
Citations
Jun 8, 2002·Biochemical and Biophysical Research Communications·Chisa ShinotsukaKazuhisa Nakayama
Oct 7, 2008·Nature Medicine·Renate KainDontscho Kerjaschki
Sep 6, 2000·Histopathology·A KollerM Susani
Jan 18, 2011·The Journal of Biological Chemistry·Zhiqiu ManHye-Won Shin
Sep 15, 2011·The Journal of Biological Chemistry·Hiroyuki TakatsuHye-Won Shin
Jun 9, 2012·The Journal of Biological Chemistry·Kensuke NakamuraSoichi Wakatsuki
Dec 27, 2007·Viral Immunology·Stéphane PaulJean-Marc Balloul
Jun 16, 2001·Molecular Biology of the Cell·J Rohrer, R Kornfeld
Sep 24, 2004·Molecular Biology of the Cell·Hye-Won ShinKazuhisa Nakayama
Jun 21, 2013·Molecular Biology of the Cell·Waka NakaiHye-Won Shin
May 30, 2006·Journal of Virology·Jacqueline FerralliManfred Heinlein
Feb 28, 2002·Journal of Virology·Regan N Theiler, Teresa Compton
Sep 13, 2000·Molecular and Cellular Biology·N VitaleM Vaughan
Jul 17, 2010·PloS One·Parveen SharmaAnthony O Gramolini
Nov 14, 2013·Archives of Virology·Shigeo NagashimaHiroaki Okamoto
Dec 22, 1998·Molecular Membrane Biology·B J ReavesG Banting
Dec 27, 2011·Toxicology and Applied Pharmacology·François MarceauGuillaume Morissette
Nov 1, 2016·Molecular Biology of the Cell·Yoshiki TanakaHye-Won Shin
Nov 7, 1999·The Journal of Biological Chemistry·R KornfeldW Canfield
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaodong WangTomas Mustelin
Jan 19, 2013·Cell Structure and Function·Hiroyuki TakatsuKazuhisa Nakayama
May 1, 2018·European Journal of Preventive Cardiology·Anna ChiariniIlaria Dal Pra
Sep 1, 2005·Journal of Cell Science·Hye-Won ShinKazuhisa Nakayama
Apr 25, 2000·Experimental Cell Research·S Y LeeB Pohajdak