PMID: 9545511Apr 18, 1998Paper

Molecular cloning and functional expression of chicken luteinizing hormone receptor

Biochimica Et Biophysica Acta
T MizutaniK Miyamoto

Abstract

A complementary DNA for chicken luteinizing hormone (LH) receptor containing the entire coding region was isolated from chicken F1 granulosa cell cDNA library. Nucleotide sequence analysis revealed that there are characteristic GC-rich regions around the N-terminal part. Chicken LH receptor consists of a 19-residue signal peptide, a 366-residue extracellular domain, a 267-residue region containing seven transmembrane segments, and a 76-residue cytoplasmic C-terminal tail. The deduced amino acid sequence of the chicken LH receptor shares 67%, 69%, and 69% identity with the human, rat and porcine LH receptor sequences, respectively, and 51% with chicken FSH receptor. However, an insertion of about 30 amino acid residues is found in chicken LH receptor in the extracellular domain about 44 amino acid residues upstream of the first transmembrane segment. In addition, alternative splicing seems likely to occur at the point where the insertion starts (nucleotide position 933), resulting in the truncated forms of chicken LH receptor with only the extracellular domain. Northern blot analysis revealed the presence of multiple transcripts of LH receptor, a major 3.0-kb and minor 7-kb and 1.5-kb bands, in chicken F1 to F3 granulosa cells. ...Continue Reading

References

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Citations

Jun 26, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·N YamamuraM Kamiyoshi
Jun 12, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·R S Kumar, J M Trant
Apr 16, 2013·Developmental and Comparative Immunology·Wongi MinHyun S Lillehoj
Jun 18, 2004·General and Comparative Endocrinology·Ana P C BluhmMaria Fátima M Lazari

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