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Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

Proceedings of the National Academy of Sciences of the United States of America

Dec 1, 1987

David J BzikJ W Inselburg

PMID: 2825189

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Abstract

Genomic DNA clones that coded for the bifunctional dihydrofolate reductase (DHFR) and thymidylate synthase (TS) (DHFR-TS) activities from a pyrimethamine-sensitive strain of Plasmodium falciparum were isolated and sequenced. The deduced DHFR-TS protein contained 608 amino acids (71,682 ...read more

Mentioned in this Paper

Citrullinemia
Enzymes, antithrombotic
Amino Acid [EPC]
Enzymes, peripheral vasodilators
Timothy Syndrome
Homologous Gene
Sequence Analysis
Pyrimethamine
Open Reading Frames
Enzymes, hematological
37
Paper Details
References
  • References33
  • Citations159
1234
  • References33
  • Citations159
12345...

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

Proceedings of the National Academy of Sciences of the United States of America

Dec 1, 1987

David J BzikJ W Inselburg

PMID: 2825189

DOI:

Abstract

Genomic DNA clones that coded for the bifunctional dihydrofolate reductase (DHFR) and thymidylate synthase (TS) (DHFR-TS) activities from a pyrimethamine-sensitive strain of Plasmodium falciparum were isolated and sequenced. The deduced DHFR-TS protein contained 608 amino acids (71,682 ...read more

Mentioned in this Paper

Citrullinemia
Enzymes, antithrombotic
Amino Acid [EPC]
Enzymes, peripheral vasodilators
Timothy Syndrome
37

Related Papers

Paper Details
References
  • References33
  • Citations159
1234
  • References33
  • Citations159
12345...

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