PMID: 8584017Oct 4, 1995Paper

Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression

Molecular and Cellular Biochemistry
B GhoshI Singh

Abstract

A complimentary DNA clone encoding the entire human palmitoyl-CoA ligase has been isolated from a liver cDNA library and sequenced in it's entirety. The predicted product is a 699 amino acid protein. Southern analysis utilizing the human palmitoyl-CoA ligase gene as a probe revealed varying degrees of similarity amongst various mammalian species. The palmitoyl-CoA ligase gene is highly expressed in liver, heart, skeletal muscle and kidney, and to a lesser extent in brain, lung, placenta and pancreas. The expression of palmitoyl-CoA ligase in various tissue parallels the function of this enzyme in the metabolism of fatty acids in these tissues.

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Citations

Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·K M Knights
Mar 8, 2005·Drug Metabolism Reviews·Haiping HaoJianguo Sun
Sep 1, 2009·Biochimica Et Biophysica Acta·Gema Pérez-ChacónJesús Balsinde
Aug 5, 2004·Journal of Lipid Research·Douglas G MashekTokuo T Yamamoto
Jul 9, 1999·Progress in Lipid Research·J C DeMarR E Anderson
Mar 1, 1997·Progress in Lipid Research·P A Watkins

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