PMID: 3755848Oct 15, 1986Paper

Molecular cloning and sequencing of the region of the rubella virus genome coding for glycoprotein E1

Virology
T K FreyG Dominguez

Abstract

The sequence of the 1600 3' terminal nucleotides of the RNA of rubella virus was determined from cDNA synthesized from both virion and intracellular RNA using reverse transcriptase and an oligodeoxythymidine primer and cloned into a bacterial plasmid vector. This sequence contained the complete coding sequence for virion envelope protein E1 and a 57 nucleotide nontranslated region between the stop codon for E1 and the poly A tract. The predicted size for E1 was 481 amino acids and within this sequence were three potential N-linked glycosylation sites and a putative trans-membrane domain near the carboxy terminus. Immediately preceding the E1 coding region was a putative signal sequence. No homology was found at either the amino acid or nucleotide level between the region of the rubella virus genome sequenced and corresponding regions of the genomes of the alphaviruses, the other genus of the family Togaviridae for which sequence information has been obtained.

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Citations

Jan 1, 1989·Archives of Virology·G M TerryK R Rees
Jan 1, 1988·Archives of Virology·G M TerryK R Rees
Jul 1, 1989·Journal of Virological Methods·W F CarmanA H Kidd
Apr 1, 1988·Virus Research·H L NakhasiT Y Liu
Jul 1, 1989·Virus Research·H L NakhasiT Y Liu
May 1, 1989·Biochimie·A de Mazancourt, M Perricaudet
Apr 1, 1993·The Journal of Cell Biology·T C HobmanM G Farquhar
Feb 1, 1988·Journal of Medical Virology·L Ho-TerryA Denissen
Jun 1, 1988·Japanese Journal of Medical Science & Biology·S Katow, A Sugiura
Mar 12, 1999·Journal of Virology·M H Chen, T K Frey
May 1, 1991·Journal of Clinical Microbiology·F A EggerdingC B Inderlied
Nov 1, 1988·Journal of Virology·T C HobmanS Gillam
Aug 1, 1991·Journal of Virology·J S WolinskyD Simmons

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