PMID: 3753936Feb 17, 1986Paper

Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons

European Journal of Biochemistry
M G WatheletJ Content

Abstract

Among the various proteins which are induced when human cells are treated with interferon, a predominant protein of unknown function, with molecular mass 56 kDa, has been observed. With the aim of exploring the molecular basis of the regulation of this protein and of its mRNA, in order to understand its biological function and its possible contribution to the various antiviral and non-antiviral actions exerted by interferons, we cloned a full-length cDNA copy of the 1.8-1.9 X 10(3)-base 56-kDa-protein mRNA and determined its sequence. The cDNA contains 1662 nucleotides derived from the 56-kDa-protein mRNA, including a poly(A) tail of 20 residues. Primer extension experiments indicate that the 5' end of this cDNA clone is probably located only 13 nucleotides downstream of the actual cap site of the 56-kDa-protein mRNA. It consists of a 64-nucleotide-long 5'-non-coding segment, a coding segment of 1434 nucleotides terminated by a TAG triplet and a 141-nucleotide 3'-non-coding segment. The encoded protein of 478 amino acid residues has a molecular mass of 55335 Da and a single potential site for N-glycosylation. The protein contains an excess of basic amino acids and most of them are localized in the carboxy-terminal half of the m...Continue Reading

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Citations

Mar 1, 1988·Somatic Cell and Molecular Genetics·M A HorisbergerJ Content
Sep 1, 1988·Somatic Cell and Molecular Genetics·M G WatheletC Szpirer
Mar 1, 1991·Breast Cancer Research and Treatment·R K TiwariM P Osborne
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ying LiHong-Bing Shu
Aug 1, 1993·Journal of Interferon Research·M J BalishC R Brandt
Oct 19, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Volker Fensterl, Ganes C Sen
Apr 11, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Nancy C Reich
Dec 1, 1987·European Journal of Biochemistry·M G WatheletG A Huez
Jun 1, 1988·European Journal of Biochemistry·M G WatheletG A Huez
Jun 8, 2007·Journal of Virology·Fulvia TerenziGanes C Sen
Sep 5, 2008·Journal of Virology·Volker FensterlGanes C Sen
Oct 7, 2011·Journal of Virology·Amit RaychoudhuriRatna B Ray
Mar 1, 2003·Journal of Virology·Vivian RuvoloSankar Swaminathan
Oct 7, 2004·Pharmacology & Therapeutics·Saumendra N Sarkar, Ganes C Sen
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Apr 30, 2013·Developmental and Comparative Immunology·Katharine E MagorAlysson H Blaine
Sep 3, 2016·Journal of Medical Virology·Li ZhangXu-Xia Song
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco J Sánchez-LuqueAlfredo Berzal-Herranz
Apr 20, 2019·The Journal of Cell Biology·Lei Song, Zhao-Qing Luo
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Sep 15, 2016·Oncotarget·Nghiem Xuan HoanThirumalaisamy P Velavan

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