PMID: 9166716Jun 1, 1997Paper

Molecular cloning of a lobster G alpha(q) protein expressed in neurons of olfactory organ and brain

Journal of Neurochemistry
Timothy S McClintockT M Landers

Abstract

We have isolated from an American lobster (Homarus americanus) olfactory organ cDNA library a clone, hG alpha(q), with >80% identity to mammalian and arthropod G alpha(q) sequences. In brain and olfactory organ, hG alpha(q) mRNA was expressed predominantly in neurons, including virtually all the neuronal cell body clusters of the brain. G alpha(q) protein was also expressed broadly, appearing on western blots as a single band of 46 kDa in brain, eyestalk, pereiopod, dactyl, tail muscle, olfactory organ, and aesthetasc hairs. These results suggest that hG alpha(q) plays a role in a wide variety of signal transduction events. Its presence in the olfactory aesthetasc hairs, which are almost pure preparations of the outer dendrites of the olfactory receptor neurons, the expression of a single hG alpha(q) mRNA species (6 kb) in the olfactory organ, and the localization of hG alpha(q) mRNA predominantly in the olfactory receptor neurons of the olfactory organ strongly suggest that one function of hG alpha(q) is to mediate olfactory transduction.

Citations

Apr 15, 2006·Physiological Genomics·Ruben StepanyanTimothy S McClintock
Oct 16, 2004·Archives of Insect Biochemistry and Physiology·Peter J K Knight, Thomas A Grigliatti
Jan 18, 2007·The Journal of Comparative Neurology·Arie Sitthichai MobleyMary T Lucero
Nov 28, 2002·The Journal of Comparative Neurology·Bettye HollinsTimothy S McClintock
May 3, 2002·European Journal of Biochemistry·Emmanuelle Jacquin-JolyRosario Maida
Jun 16, 2000·Physiology & Behavior·C D Derby

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