PMID: 9191111Jun 1, 1997Paper

Molecular cloning of a new unc-33-like cDNA from rat brain and its relation to paraneoplastic neurological syndromes

Brain Research. Molecular Brain Research
T T QuachJ Honnorat

Abstract

Anti-CV2-autoantibodies from patients with paraneoplastic neurological syndromes were used to purify protein(s) related to this disease. A novel cDNA, c-22, was obtained by PCR with primers based on amino-acid sequence of peptides obtained from this protein and rat brain cDNA as template. The deduced amino-acid sequence of c-22 shows homology to the Unc-33 gene from C. elegans in which mutations lead to defects in neuritic outgrowth and axonal guidance and cause uncoordinated movements of the nematode. Several consensus sites for putative protein kinase C phosphorylation were found, suggesting that the c-22 gene product may be a phosphoprotein. Northern hybridizations show that the apparently unique 3.8-kb mRNA of c-22 is present in rat brain tissue and its expression is developmentally regulated: the levels of C-22 mRNA, detectable in brain at embryonic day 17 (E17), increase up to post-natal day 7 (P7) and decline rapidly to an almost undetectable level in adult.

References

Jan 1, 1987·Developmental Neuroscience·A M DucheminR J Wyatt
May 8, 1995·The Journal of Comparative Neurology·J E MinturnS Hockfield
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R B Darnell
Sep 3, 2004·Journal of Pediatric Hematology/oncology·Jerome B Posner

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Citations

Mar 23, 2004·Molecular and Cellular Neurosciences·Tam Thanh QuachPappachan E Kolattukudy
Dec 14, 1999·The European Journal of Neuroscience·J HonnoratJ C Antoine
Nov 24, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Emmanuelle CharrierPappachan Kolattukudy
Jun 17, 2015·Molecular Psychiatry·T T QuachA M Duchemin
Aug 18, 2020·Journal of Alzheimer's Disease : JAD·Tam T QuachRuth M Barrientos
Jul 23, 2013·Journal of Cell Science·Tam T QuachAnne-Marie Duchemin

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