PMID: 9427525Jan 14, 1998Paper

Molecular cloning of a novel member of semaphorin family genes, semaphorin Z

Brain Research. Molecular Brain Research
K KikuchiT Kimura

Abstract

Semaphorins/collapsins (semaphorins) comprise a large family of proteins implicated in axonal guidance during development. We cloned a novel member (semaZ) of the semaphorin gene family from a rat brain cDNA library. Sema Z was thought to be an integral membrane glycoprotein of 887 amino acids including a sema domain composed of 532 amino acids. The amino acid sequence of Sema Z showed 28-35% identity with other semaphorins in its sema domain, including 15 conserved cysteine residues. The cytoplasmic domain of Sema Z was found to be rich in prolines. Our phylogenetic analysis based on the amino acid sequence of the sema domains and the location of conserved N-glycosylation sites suggested that the sema domain of Sema Z belongs to a new class, class VI. We detected the semaZ mRNA in the first branchial arch of embryonic day 11 (E11) rat embryo, and subsequently in the myotomes and the dorsal root ganglia in developing somites from E11.5 through E13.5, but not in the brain. However, at E15, 18, 21 and P0, semaZ was highly expressed in the brain. Sema Z might play a role in both peripheral and central nervous system development.

References

Jan 1, 1991·Annual Review of Neuroscience·S K McConnell
Oct 1, 1985·Virus Research·D J McGeoch
Jun 11, 1986·Nucleic Acids Research·G von Heijne
May 28, 1985·Biochimica Et Biophysica Acta·P KleinC DeLisi
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Feb 16, 1995·Nature·T Pawson
Oct 20, 1995·Cell·R Keynes, G M Cook
Aug 21, 1995·FEBS Letters·S InagakiY Iwahashi
Jan 10, 1996·Developmental Biology·I ShepherdS Chang
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y SekidoJ D Minna
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·K T HallG J Freeman
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Aug 1, 1996·Computer Applications in the Biosciences : CABIOS·R D Page
Dec 27, 1996·The Journal of Biological Chemistry·T FuruyamaM Tohyama

❮ Previous
Next ❯

Citations

Jan 13, 2004·Biochemical and Biophysical Research Communications·Masahiko Taniguchi, Takao Shimizu
May 15, 2003·Biochemical and Biophysical Research Communications·Donald E Riley, John N Krieger
Feb 13, 1999·Progress in Neurobiology·M J Millan
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Robert P KrugerKun-Liang Guan
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A VezzaniT Bartfai
Apr 15, 1999·Annual Review of Neuroscience·B K Mueller
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A EncinasT Kimura
Jan 31, 2004·The European Journal of Neuroscience·Patrick KüryHans Werner Müller
Jun 30, 2000·Japanese Journal of Pharmacology·Y GoshimaT Kimura
Mar 2, 1999·Molecular and Cellular Neurosciences·K KikuchiT Kimura
Jul 24, 1998·Molecular and Cellular Neurosciences·S M CatalanoA Chédotal
Jan 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M C HalloranJ Y Kuwada
Jun 5, 2004·Genomics·Philippe ColletMichel Dauça
Apr 10, 1999·Nature Neuroscience·T TakahashiS M Strittmatter
Mar 10, 2001·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C A CohenL LeDuc
Mar 3, 2005·Reproduction, Fertility, and Development·Han-Seung KangDong-Kyoo Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.