PMID: 2496682Feb 1, 1989Paper

Molecular cloning of alpha-amylase genes from Drosophila melanogaster. III. An inversion at the Amy locus in an amylase-null strain

Biochemical Genetics
P E Schwartz, W W Doane

Abstract

Overlapping clones of the structural gene region for alpha-amylase, Amy, were isolated from a lambda EMBL4 library containing genomic DNA fragments from an amylase-null strain of Drosophila melanogaster. Southern blot analysis and restriction endonuclease mapping of the cloned region indicate that it contains an Amy gene duplication within an inverted repeat sequence as is characteristic of the genomic arrangement for this species. Spacing between the cloned gene copies is similar to that commonly found in other strains. Evidence is presented for the presence of an inversion 4 to 9 kb in length within the cloned Amy region of the null strain. We postulate a causal relationship between the presence of the inversion and the failure of individuals from the null strain to express amylase. A model is proposed that suggests the inversion may have arisen through intramolecular (or sister-strand) recombination mediated by homologous pairing of the inverted repeat sequences at the Amy locus.

References

Aug 1, 1990·Genome Génome / Conseil National De Recherches Canada·S A HawleyD A Hickey
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B I EisensteinD I Friedman
Jul 11, 1986·Nucleic Acids Research·R M GemmillW W Doane
Jun 1, 1987·Genome Génome / Conseil National De Recherches Canada·B F BenkelD A Hickey
Mar 21, 1986·Journal of Theoretical Biology·A B Futcher
Apr 1, 1967·The Journal of Experimental Zoology·W W Doane
Sep 25, 1984·Nucleic Acids Research·P A Krieg, D A Melton
Nov 15, 1983·Journal of Molecular Biology·A M FrischaufN Murray
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B F Benkel, D A Hickey

❮ Previous
Next ❯

Citations

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D A HickeyB F Benkel
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J GubbayR Lovell-Badge
Jul 21, 1998·Genes, Chromosomes & Cancer·S PedemonteL Varesco
Oct 28, 1992·Annals of the New York Academy of Sciences·K ZatloukalM L Birnstiel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.