Molecular cloning of canine Mcl-1 gene and its expression in tumor cell lines

The Journal of Veterinary Medical Science
Junichi SanoAtsuhiko Hasegawa

Abstract

The canine Mcl-1 gene was cloned and sequenced. Canine Mcl-1 clone was 2694 base pairs in length and encoded 350 amino acids. The predicted amino acid sequence was 87.7%, 77.1% and 75.7% homologous to predicted human, mouse and rat Mcl-1, respectively. RT-PCR analysis revealed that canine Mcl-1 mRNA was expressed in PBMCs (peripheral blood mononuclear cells), bone marrow cells, MDCK (Madin-Darby canine kidney) and GL-1 (canine B cell leukemia) whereas undetectable in CL-1 (canine T cell lymphoma) cell line.

References

Jul 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·C R GaushT F Smith
Feb 1, 1995·Seminars in Cancer Biology·R W Craig
Jun 1, 1995·Current Biology : CB·G Häcker, D L Vaux
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KozopasR W Craig
May 1, 1996·The Journal of Veterinary Medical Science·M NakaichiS Nakama
Jan 23, 1998·Veterinary Immunology and Immunopathology·Y MomoiA Hasegawa
Apr 4, 1998·American Journal of Respiratory Cell and Molecular Biology·A DruilheM Pretolani
Aug 26, 1998·Biochemical and Biophysical Research Communications·P I ChuangJ M Harlan
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ShimizuY Tsujimoto
Feb 13, 2001·The Journal of Clinical Investigation·P K Epling-BurnetteT P Loughran
Feb 15, 2001·Cell Death and Differentiation·M H Harris, C B Thompson
May 20, 2003·The Journal of Pathology·George Z RassidakisL Jeffrey Medeiros
May 20, 2003·The Journal of Pathology·Chun-Lei ZhangUdo Döbbeling

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Citations

Feb 7, 2016·Research in Veterinary Science·S de BrotF Guscetti

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