PMID: 11918633Mar 29, 2002Paper

Molecular cloning of four lambda light chain cDNAs from the Australian brushtail possum Trichosurus vulpecula

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
Katherine BelovD W Cooper

Abstract

A brushtail possum mesenteric lymph node cDNA library was screened with a grey short-tail opossum Clambda probe and four immunoglobulin lambda cDNAs were isolated. Two of the isolated clones (L5 and L10) contained identical framework 4 regions and constant regions (but different variable regions), suggesting that the possum lambda locus is organized as multiple J-C pairs--a feature seen in the opossum and placental mammals. The cloning of the lambda light chain cDNAs signifies the completion of the basic molecular characterization of the brushtail possum immunoglobulin repertoire. The availability of this sequence data will allow extensive analysis of the immune response of the brushtail possum at the molecular level, as well as the development of specific immunological reagents for detection of immunoglobulin molecules at the protein level.

References

Jan 1, 1996·Reproduction, Fertility, and Development·P E Cowan
Aug 1, 1996·Computer Applications in the Biosciences : CABIOS·R D Page
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A JankeU Arnason
Apr 13, 2000·Veterinary Immunology and Immunopathology·B M BuddleM A Chambers
May 4, 2000·Current Topics in Microbiology and Immunology·E BengténG W Warr
Apr 9, 2001·Veterinary Immunology and Immunopathology·K BelovD W Cooper

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Citations

Sep 15, 2005·Immunogenetics·Michelle L BakerSandra Brumburgh
Aug 23, 2011·BMC Immunology·Emily S W WongKatherine Belov
Nov 26, 2015·Developmental and Comparative Immunology·Julie M Old
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle L BakerRobert D Miller

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