PMID: 9524238Apr 3, 1998Paper

Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver

Biochimica Et Biophysica Acta
S YamagoeK Suzuki

Abstract

We previously reported the purification and amino acid sequence of a novel neutrophil chemotactic protein termed LECT2 (leukocyte cell-derived chemotaxin 2). In this paper we report molecular cloning of human and bovine LECT2 cDNAs based on the amino acid sequence of the purified protein. The deduced amino acid sequence of human LECT2 (hLECT2) shows an 86% identity to bovine LECT2 (bLECT2). The deduced primary structures of LECT2 were highly homologous to the repeated units of Mim-1 protein (myb induced myeloid protein-1). The mim-1 gene is one of the known myb target genes and is specifically expressed in normal and transformed immature granulocytes in the chicken. Northern blot analysis of normal human tissues demonstrated that the hLECT2 gene is specifically expressed in the adult and fetal livers. In addition, several human hepatoma cell lines also expressed LECT2 mRNA, suggesting that hepatic cells in the liver produce LECT2 protein.

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Citations

Nov 7, 2012·Fish Physiology and Biochemistry·Tian YuanHeng Xu
Dec 1, 1998·Pathology International·H NagaiK Suzuki
Dec 3, 2014·Fish & Shellfish Immunology·Jiong ChenChang-Hong Li
Jan 23, 2013·Protein Expression and Purification·Hai ZhengMasaru Tanokura
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christine OvejeroChristine Perret
May 2, 2008·Kidney International·Merrill D BensonBarbara Kluve-Beckerman
Jan 29, 2013·FEBS Letters·Akinori OkumuraSatoshi Yamagoe
Apr 7, 2016·BBA Clinical·Tae Woo JungKyung Mook Choi
Oct 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Kuan ChenMin-Liang Kuo
Jan 21, 2015·The American Journal of Surgical Pathology·Vishal S ChandanTsung-Teh Wu
Mar 23, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Hai ZhengMasaru Tanokura
Jun 23, 2010·Annual Review of Genomics and Human Genetics·Christophe M LefèvreKevin R Nicholas
Nov 7, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akinori OkumuraYasushi Kaburagi
Oct 31, 2009·Reproduction, Fertility, and Development·Christophe M LefèvreKevin R Nicholas
Dec 14, 2016·Annual Review of Pathology·Ahmet Dogan
Jun 18, 2017·Nature Reviews. Endocrinology·Ruth C R Meex, Matthew J Watt
May 4, 2017·Clinical and Translational Science·V Slowik, U Apte
Apr 14, 2018·Journal of Molecular Endocrinology·Tae Woo JungJi Hoon Jeong
Sep 5, 2019·Asian-Australasian Journal of Animal Sciences·Seokhyun LeeKi-Duk Song
Oct 2, 2020·BMC Genomics·J L BrittS K Duckett
Jan 4, 2019·Diabetology International·Hirofumi Misu
May 16, 2003·Journal of Food Protection·Tawni L CrippenMichael H Kogut
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takeshi SaitoSatoshi Yamagoe
Feb 22, 2018·Case Reports in Nephrology and Dialysis·Gagandeep KaurBijin Thajudeen

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