Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

Neuroscience
J P MerlioH Persson

Abstract

Tyrosine protein kinases trk, trkB and trkC are signal-transducing receptors for the neurotrophins nerve growth factor, brain-derived nerve growth factor, neurotrophin-3 and neurotrophin-4. Here we report on the isolation of cDNA fragments encoding a part of rat trk and trkB proteins, respectively, and characterization of a full-length cDNA clone encoding rat trkC. Cells expressing mRNAs for the different members of the trk family were identified in the rat central nervous system by in situ hybridization using oligonucleotide probes designed from the isolated cDNA sequences and complementary to mRNA sequences coding for the extracellular region of the receptors. The expression of trk mRNA was found to be restricted to neurons of the basal forebrain, caudate-putamen with features of cholinergic cells and to magnocellular neurons of several brainstem nuclei. In contrast, cells expressing trkB and trkC mRNAs were widely distributed in the brain. Areas expressing high levels of trkB or trkC mRNAs included olfactory formations, neocortex, hippocampus, thalamic and hypothalamic nuclei, brainstem nuclei, cerebellum and spinal cord motoneurons. A similar distribution for trkB and trkC mRNAs was shown in most areas but each probe specif...Continue Reading

References

Jun 10, 1996·The Journal of Comparative Neurology·E Y ChenJ H Kordower
Oct 7, 1996·The Journal of Comparative Neurology·R H FryerL F Kromer
Feb 10, 1999·The Journal of Comparative Neurology·E CaminosE Vecino
May 15, 1997·Journal of Neuroscience Research·M J SchaafE Vreugdenhil
Apr 23, 1999·Journal of Neuroscience Research·C F DreyfusI B Black
Nov 1, 1994·Journal of Neurobiology·A M Davies
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Mar 14, 2009·Experimental Brain Research·Jennifer Rodger, Douglas O Frost
Aug 10, 2004·Cell and Tissue Research·Kerstin Krieglstein
Aug 31, 1995·Mechanisms of Ageing and Development·J M TorresJ A Vega
Oct 15, 1993·Brain Research. Developmental Brain Research·R WilliamsF Hallböök
Mar 19, 1993·Brain Research. Developmental Brain Research·T RingstedtH Persson
Apr 18, 1995·Brain Research. Developmental Brain Research·T KuboH Hatanaka
May 1, 1994·Trends in Neurosciences·R M LindsayP S DiStefano
Oct 1, 1994·Brain Research. Molecular Brain Research·H M Chao, B S McEwen
Sep 1, 1994·Brain Research. Molecular Brain Research·A J MacLennanD C Lado
Apr 1, 1994·Brain Research. Molecular Brain Research·J E SpringerF M Sessler
Jun 1, 1995·Brain Research. Molecular Brain Research·M DragunowL F Nicholson

Citations

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N Y IpS Squinto
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B KnüselF Hefti
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P ErnforsH Persson
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K R Jones, L F Reichardt
Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Jun 1, 1989·Neuron·Y A Barde

Related Concepts

Neurotrophic Tyrosine Kinase Receptor Type 2
Central Nervous System
Entire Brainstem
Neostriatum
Extracellular
Malignant Neoplasm of Spinal Cord
Neurons
NTRK3 wt Allele
Brain
NTRK2 gene

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.