Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene

Genomics
S YamagoeK Suzuki

Abstract

We originally isolated LECT2 (leukocyte cell-derived chemotaxin 2) as a 16-kDa secreted protein having a human neutrophil chemotactic activity, then cloned human and bovine LECT2 cDNAs and demonstrated the liver-specific expression of the protein. LECT2 is thought to be a multifunctional protein, because it was recently found to be identical to chondromodulin-II a growth stimulator of chondrocyte cells. We report here the cloning and the structural analysis of the human LECT2 gene. The gene spans approximately 8 kb and consists of four exons and three introns. Primer extension analysis revealed that several transcription initiation sites occur within 70-230 nucleotides upstream of the translation initiation codon. Several transcriptional control sequences relevant to the liver-specific expression have been identified at the 5' untranslated region of the human LECT2 gene. The human LECT2 gene was mapped to chromosome 5q31.1-q32 by fluorescence in situ hybridization. This region contains a cluster of cytokine genes including IL-4, IL-5, and IL-9.

References

Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Jan 1, 1982·Annual Review of Physiology·E Schiffmann

❮ Previous
Next ❯

Citations

Apr 9, 2015·Clinical Kidney Journal·Mazdak A KhalighiMiguel F Palma-Diaz
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Pablo LibradoLudovic Orlando
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christine OvejeroChristine Perret
May 2, 2008·Kidney International·Merrill D BensonBarbara Kluve-Beckerman
Oct 19, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Charles L MurphyAlan Solomon
Jan 21, 2015·The American Journal of Surgical Pathology·Vishal S ChandanTsung-Teh Wu
Dec 14, 2016·Annual Review of Pathology·Ahmet Dogan
May 4, 2017·Clinical and Translational Science·V Slowik, U Apte
Feb 5, 2019·Pediatric Transplantation·Eliah R ShamirVighnesh Walavalkar
Apr 16, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Samih H NasrChristopher P Larsen
Aug 9, 2020·Scientific Reports·Akihiro KikuchiToshinari Takamura
Nov 7, 2012·Fish Physiology and Biochemistry·Tian YuanHeng Xu
Feb 23, 2021·The Journal of Biological Chemistry·Jeung-Hoi HaStewart N Loh
May 5, 2001·Experimental Gerontology·K H Krause, R A Clark
Sep 23, 2021·Journal of Cellular Physiology·Sipin ZhuJiake Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.