Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours

BMC Research Notes
Sally M HunterKylie L Gorringe

Abstract

Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously shown that 40% of benign serous ovarian tumours are likely primary fibromas due to the neoplastic alterations being restricted to the stromal compartment of these tumours. We further explore this finding by comparing benign serous tumours to pure fibromas. Performing copy number aberration (CNA) analysis on the stromal component of 45 benign serous tumours and 8 pure fibromas, we have again shown that trisomy of chromosome 12 is the most common aberration in ovarian fibromas. CNAs were more frequent in the pure fibromas than the benign serous tumours (88% vs 33%), however pure fibromas more frequently harboured more than one CNA event compared with benign serous tumours. As these extra CNA events observed in the pure fibromas were unique to this subset our data indicates a unique tumour evolution. Gene expression analysis on the two cohorts was unable to show gene expression changes that differed based on tumour subtype. Exome analysis did not reveal any recurrently mutated genes.

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Datasets Mentioned

BETA
PRJNA631561

Methods Mentioned

BETA
PCR
exome sequencing

Software Mentioned

GATK
MuTect
transFIC ( Transformed Functional Impact for Cancer )
BWA
GATK Unified Genotyper
Cytoband
VarScan2
Joint
Partek Gene Expression
Partek Genomics Suite

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