Molecular components of physiological stress responses in Escherichia coli

Advances in Biochemical Engineering/biotechnology
Lukas M Wick, Thomas Egli

Abstract

In order to survive under and adapt to different conditions Escherichia coli has evolved elaborate systems that are able to sense and respond to environmental stimuli. Very often, different stresses act on a bacterium simultaneously and a variety of stresses have similar effects on cellular molecules and processes. Therefore, the various stress response systems have to interact (cross talk) with each other. A complex network of global regulatory systems with a multitude of molecular components ensures a coordinated and effective answer. Such regulatory components include DNA, mRNAs, sRNAs, proteins, such as DNA-and RNA binding proteins, alternative sigma factors and two-component systems, as well as small molecular weight molecules, as for example (p)ppGpp. These regulatory systems govern the expression of a plethora of further effectors that aim at maintaining stability of the cellular equilibrium under the various conditions. Using five of the most important stress response systems, we will discuss the roles and mechanisms of such regulatory and effector molecules in more detail. The heat shock response, controlled by the sigma factor sigma32, and the envelope stress response, controlled by the sigma factor sigmaE and the Cpx...Continue Reading

Citations

Mar 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ferric C Fang
Sep 23, 2008·Applied and Environmental Microbiology·K LemuthM Siemann-Herzberg
May 6, 2020·Biotechnology and Bioengineering·Jashwant KumarAnurag S Rathore
Jun 23, 2006·Infection and Immunity·Brian HendersonAnthony R M Coates
Mar 15, 2016·Frontiers in Cellular and Infection Microbiology·Shiyun ChenMatthew S Francis
Jul 14, 2020·Frontiers in Microbiology·Sviatlana MarozavaRainer U Meckenstock
Apr 7, 2009·Applied and Environmental Microbiology·Teresa M BergholzThomas S Whittam
Mar 25, 2008·Journal of Bacteriology·Thusitha S GunasekeraOleg Paliy
Nov 14, 2013·PloS One·Mónica Aguado-UrdaGuillermo H López-Campos
Apr 7, 2006·Applied and Environmental Microbiology·Michael BerneyThomas Egli

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