PMID: 8947556Dec 1, 1996Paper

Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments

The Journal of Cell Biology
J Q DavisV Bennett

Abstract

Neurofascin, NrCAM, L1, and NgCAM are a family of Ig/FNIII cell adhesion molecules that share ankyrin-binding activity in their cytoplasmic domains, and are candidates to form membrane-spanning complexes with members of the ankyrin family of spectrin-binding proteins in a variety of cellular contexts in the nervous system. Specialized forms of ankyrin, 270 kD and/or 480 kD ankyrinG are components of the membrane undercoat of axons at the node of Ranvier. This paper focuses on definition of the isoforms of ankyrin-binding cell adhesion molecules localized with ankyrinG at the nodal axon segment. The exon usage of two major forms of neurofascin was determined by isolation of full-length cDNAs and used to prepare isoform-specific antibodies. An isoform of neurofascin containing a mucin-like domain and lacking the third FNIII domain was concentrated at axon initial segments and colocalized at nodes of Ranvier with ankyrinG and the voltage-dependent sodium channel. An alternative form of neurofascin lacking the mucin-like domain and containing the third FNIII domain was present in unmyelinated axons. The antibody initially raised against neurofascin was used to screen a rat brain cDNA expression library. In addition to neurofascin, ...Continue Reading

References

Mar 1, 1991·Journal of Neurocytology·W L MaxwellM Sturatis
Aug 1, 1991·Journal of Neurocytology·T Ichimura, M H Ellisman
Jan 1, 1991·Annual Review of Cell Biology·M Hortsch, C S Goodman
Oct 1, 1991·Current Opinion in Neurobiology·M Grumet
Jan 1, 1990·Annual Review of Neuroscience·J W Fawcett, R J Keynes
Aug 1, 1990·Trends in Biochemical Sciences·N Jentoft
Aug 1, 1986·The Journal of Cell Biology·F RiegerG M Edelman
May 5, 1986·Journal of Molecular Biology·F W Studier, B A Moffatt
Dec 1, 1984·Journal of Neurochemistry·R H Quarles, B D Trapp
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·V Bennett, J Davis
Dec 16, 1993·Nature·Y Shimizu, S Shaw
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Varki
Feb 1, 1993·Annals of Neurology·S G Waxman, J M Ritchie
Jan 1, 1993·Annual Review of Cell Biology·V Bennett, D M Gilligan

❮ Previous
Next ❯

Citations

Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·B E Porter, G Tennekoon
Mar 27, 2001·Muscle & Nerve·R Martini
May 20, 1998·Molecular Neurobiology·K C BreenF D Hayes
May 7, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tobias DerfussEdgar Meinl
Nov 25, 2003·Current Opinion in Neurobiology·Manzoor A Bhat
Dec 26, 2002·Biology of the Cell·Julien FalkCatherine Faivre-Sarrailh
Feb 13, 2001·Current Opinion in Cell Biology·V Bennett, L Chen
Nov 21, 2000·Current Opinion in Neurobiology·E Peles, J L Salzer
Oct 9, 2002·Current Opinion in Neurobiology·Jean-Antoine Girault, Elior Peles
May 6, 1998·Current Opinion in Neurobiology·T BrümmendorfF G Rathjen
Jul 4, 2012·Journal of Proteome Research·Sandra PacharraIsabelle Breloy
Dec 20, 2003·Nature Reviews. Neuroscience·Sebastian Poliak, Elior Peles
Aug 21, 2007·Nature Reviews. Neuroscience·Z J HuangF Ango
Apr 10, 2002·Journal of the Peripheral Nervous System : JPNS·Steven S Scherer, Edgardo J Arroyo
Apr 10, 2013·The Journal of Biological Chemistry·Meng HeVann Bennett
Sep 12, 2007·The Journal of Experimental Medicine·Emily K MatheyChristopher Linington
Jul 16, 2004·Molecular Biology of the Cell·Julien FalkCatherine Faivre-Sarrailh
Oct 28, 2008·Brain : a Journal of Neurology·Aurélie Lonigro, Jérôme J Devaux
Jul 21, 2009·Human Molecular Genetics·Kakanahalli NagarajMichael Hortsch
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Vann Bennett, Jane Healy
Dec 10, 1999·Annals of the New York Academy of Sciences·S S Scherer
Nov 19, 2003·BMC Neuroscience·Laurence GoutebrozeJean-Antoine Girault
May 1, 2005·Future Cardiology·Peter J MohlerSydika Banks
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuanzheng GaoJeffrey D Rothstein
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ido HorreshElior Peles
Apr 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Courtney ThaxtonManzoor A Bhat
Jan 1, 2003·Journal of Neurosurgery·Thomas KretschmerDavid G Kline
Apr 11, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne DesmazieresPeter J Brophy
Jun 2, 2012·Neural Plasticity·Carlo Natale Giuseppe GiachelloMirella Ghirardi
Feb 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Scott M Jenkins, Vann Bennett
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Maria Carmen IndaAlberto Muñoz
Nov 5, 2014·Nature Neuroscience·Kae-Jiun ChangMatthew N Rasband

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.