Molecular Composition of Vestibular Hair Bundles

Cold Spring Harbor Perspectives in Medicine
J F Krey, P G Barr-Gillespie

Abstract

The vertebrate hair bundle, responsible for transduction of mechanical signals into receptor potentials in sensory hair cells, is an evolutionary masterpiece. Composed of actin-filled stereocilia of precisely regulated length, width, and number, the structure of the hair bundle is optimized for sensing auditory and vestibular stimuli. Recent developments in identifying the lipids and proteins constituting the hair bundle, obtained through genetics, biochemistry, and imaging, now permit a description of the consensus composition of vestibular bundles of mouse, rat, and chick.

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Citations

Jan 9, 2019·Cold Spring Harbor Perspectives in Medicine·Guy P Richardson, Christine Petit
May 26, 2021·Current Biology : CB·Anne Houdusse, Margaret A Titus
Nov 9, 2021·Frontiers in Cell and Developmental Biology·Haibo DuZhigang Xu

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