PMID: 1206491Dec 1, 1975Paper

Molecular connectivity. I: Relationship to nonspecific local anesthesia

Journal of Pharmaceutical Sciences
L B KierM Randic

Abstract

A very significant linear correlation was found between a recently proposed connectivity index and molecular polarizability, cavity surface areas calculated for water solubility of alcohols and hydrocarbons, and biological potencies of nonspecific local anesthetics. The simplicity of calculation of the index from the connectivity in the molecular skeleton, together with the very significant correlation, indicates its practical value.

References

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Citations

Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·A M MohamedG A Saleh
Oct 26, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·A K Singh
Jan 5, 2002·Journal of Molecular Graphics & Modelling·L H Hall, L B Kier
Jan 5, 2002·Journal of Molecular Graphics & Modelling·M Randić
Jan 5, 2002·Journal of Molecular Graphics & Modelling·D Bonchev
Jan 5, 2002·Journal of Molecular Graphics & Modelling·L B Kier, L H Hall
Mar 28, 2006·Journal of Chemical Information and Modeling·Scott OloffAlexander Tropsha
Nov 8, 2001·SAR and QSAR in Environmental Research·D Bonchev, N Trinajstić
Jul 12, 2003·SAR and QSAR in Environmental Research·D Bonchev
Aug 1, 1978·The Journal of Pharmacy and Pharmacology·J S Millership, A D Woolfson
May 19, 2010·International Journal of Molecular Sciences·Zuojing LiFanhao Meng
Dec 1, 1976·Journal of Pharmaceutical Sciences·L B Kier, L H Hall
Aug 1, 1976·Journal of Pharmaceutical Sciences·L B KierL H Hall
Apr 1, 1992·Journal of Pharmaceutical Sciences·L Pogliani
Jun 5, 2007·Journal of Pharmaceutical Sciences·Lionello Pogliani
Mar 3, 2006·Journal of Molecular Graphics & Modelling·L P ZhouZ L Li
Oct 1, 1978·Journal of Pharmaceutical Sciences·L B Kier, L H Hall
Aug 28, 2004·Journal of Molecular Graphics & Modelling·Rajarshi GuhaPeter C Jurs
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan CiubotariuSeiman Corina
Dec 1, 1975·Journal of Pharmaceutical Sciences·L H HallW J Murray
Dec 1, 1975·Journal of Pharmaceutical Sciences·W J MurrayL B Kier
Oct 1, 2014·Molecular Informatics·Li LiYuh-Shan Ho
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Sep 1, 2011·Molecular Informatics·Charles BergeronKristin P Bennett
Mar 1, 1982·The Journal of Pharmacy and Pharmacology·J C BoydA D Woolfson
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·J S Millership, A D Woolfson
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Jan 1, 1998·Analytical Chemistry·S Fu, C A Lucy
Jul 23, 2003·Journal of Chemical Information and Computer Sciences·Jorge Galvez
Jan 24, 2006·Journal of Chemical Information and Modeling·Debojyoti DuttaTing Chen

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