Molecular conservation and differential mutation on ORF3a gene in Indian SARS-CoV2 genomes

Genomics
Sk Sarif HassanS. S. Jana

Abstract

A global emergency due to the COVID-19 pandemic demands various studies related to genes and genomes of the SARS-CoV2. Among other important proteins, the role of accessory proteins are of immense importance in replication, regulation of infections of the coronavirus in the hosts. The largest accessory protein in the SARS-CoV2 genome is ORF3a which modulates the host response to the virus infection and consequently it plays an important role in pathogenesis. In this study, an attempt is made to decipher the conservation of nucleotides, dimers, codons and amino acids in the ORF3a genes across thirty-two genomes of Indian patients. ORF3a gene possesses single and double point mutations in Indian SARS-CoV2 genomes suggesting the change of SARS-CoV2's virulence property in Indian patients. We find that the parental origin of the ORF3a gene over the genomes of SARS-CoV2 and Pangolin-CoV is same from the phylogenetic analysis based on conservation of nucleotides and so on. This study highlights the accumulation of mutation on ORF3a in Indian SARS-CoV2 genomes which may provide the designing therapeutic approach against SARS-CoV2.

References

May 16, 2003·The New England Journal of Medicine·Kathryn V Holmes
Mar 23, 2004·Nature Medicine·Lia van der HoekBen Berkhout
Dec 5, 2008·Microbiology and Molecular Biology Reviews : MMBR·Matthew Frieman, Ralph Baric
Oct 29, 2010·Journal of Bioinformatics and Computational Biology·Fredrik Johansson, Hiroyuki Toh
Apr 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kam-Leung SiuDong-Yan Jin
Feb 23, 2020·Journal of Medical Virology·Silvia AngelettiMassimo Ciccozzi
Mar 30, 2020·Cell·Yong-Zhen Zhang, Edward C Holmes
Apr 1, 2020·International Journal of Biological Sciences·Jun Zheng
Apr 9, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Leila Mousavizadeh, Sorayya Ghasemi

❮ Previous
Next ❯

Citations

Aug 25, 2020·Indian Journal of Clinical Biochemistry : IJCB·Subir Kumar Das
Oct 14, 2020·Journal of Medical Virology·María Teresa Hernández-HuertaCarlos Alberto Matias-Cervantes
Oct 23, 2020·Genomics·Mhamad Abou-HamdanFadi Abdel-Sater
Jan 22, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Antara SenguptaPabitra Pal Choudhury
Jan 23, 2021·Advanced Drug Delivery Reviews·Saborni ChakrabortyTaia T Wang
Aug 22, 2020·Genomics·Sk Sarif HassanSiddhartha Sankar Jana
Mar 20, 2021·Virus Research·Md Mahbub HasanAdnan Mannan
Apr 17, 2021·International Journal of Biological Macromolecules·Sk Sarif HassanAdam M Brufsky
Jun 30, 2021·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Sunil Thomas

❮ Previous
Next ❯

Datasets Mentioned

BETA
MT412246
MT419822
MT412219
MT040335
MT040333

Software Mentioned

blastp suite

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved