Molecular cues on obesity signals, tumor markers and endometrial cancer

Hormone Molecular Biology and Clinical Investigation
Danielle Daley-BrownRuben R Gonzalez-Perez

Abstract

Tumor markers are important tools for early diagnosis, prognosis, therapy response and endometrial cancer monitoring. A large number of molecular and pathologic markers have been described in types I and II endometrial cancers, which has served to define the main oncogenic, epidemiological, genetic, clinical and histopathological features. Ongoing attempts to stratify biological markers of endometrial cancer are presented. However, data on changes in tumor marker profiles in obesity-related endometrial cancer are scarce. Obesity is a pandemic in Western countries that has an important impact on endometrial cancers, albeit through not very well-defined mechanisms. Although endometrial cancer is more common in Caucasian women, higher mortality is found in African Americans who also show higher incidence of obesity. Here, we describe how obesity signals (estrogen, leptin, leptin induced-molecules, Notch; cytokines and growth factors) could affect endometrial cancer. Leptin signaling and its crosstalk may be associated to the more aggressive and poor prognosis type II endometrial cancer, which affects more postmenopausal and African-American women. In this regard, studies on expression of novel molecular markers (Notch, interleukin...Continue Reading

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Citations

Mar 29, 2016·World Journal of Methodology·Crystal C LipseyRuben R Gonzalez-Perez
Jun 24, 2017·World Journal of Clinical Oncology·Cynthia I Tchio ManthoRuben R Gonzalez-Perez
Apr 26, 2017·World Journal of Clinical Oncology·Pierre V CandelariaRuben R Gonzalez-Perez
Jun 30, 2018·Endocrinology·Katie K Crean-Tate, Ofer Reizes
Jul 1, 2017·Disease Markers·Danielle Daley-BrownRuben Rene Gonzalez-Perez
Aug 2, 2019·World Journal of Clinical Oncology·Danielle Daley-BrownRuben Rene Gonzalez-Perez
Nov 2, 2018·Cancers·Subhransu S SahooPradeep S Tanwar
Jun 14, 2020·International Journal of Molecular Sciences·Dariusz DąbruśDariusz Boroń
Jan 17, 2021·Journal of Clinical Medicine·Mariana S ParahulevaNikoleta Parahuleva
Jul 27, 2021·Frontiers in Oncology·Vanessa M López-OzunaWalter H Gotlieb

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Methods Mentioned

BETA
biopsies
GTPase
hysterectomy
dissection
xenograft

Software Mentioned

EmCa

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