PMID: 9172003Jun 1, 1997Paper

Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization

Genes, Chromosomes & Cancer
Herve Avet-LoiseauM G Pallavicini

Abstract

Comparative genomic hybridization (CGH) was used to identify recurrent regions of DNA sequence loss and gain in 21 multiple myeloma (MM) and plasma cell leukemia (PCL) primary tumor specimens and cell lines. Multiple regions of non-random sequence loss and gain were observed in 8/8 primary advanced stage tumors and 13/13 cell lines. Identification of sequence copy number changes was facilitated by statistical analyses that reduce subjectivity associated with identification of copy number changes and by requiring that sequence changes are visible using both red- and green-labeled tumor DNA. Loss of sequence on 13q and 14q and gain of sequence on 1q and chromosome 7 occurred in 50-60% of the population. In general, cell lines carry more and larger regions of sequence gain and loss than primary tumors. Regions of sequence copy number change that recur among MM cell lines and primary tumors include, in order of prevalence, enh(1q12qter), dim(13), enh(7), enh(3q22q29), enh(11q13.3qter), dim(14q11.2q31), enh(8q21qter), enh(3p25pter), dim(17p11.2p13), and dim(6q22.1q23). Population distributions of genome-wide changes in primary tumors reveal "hot-spots" of sequence loss from 13q12.1-q21, 13q32-q34, 14q11.2-q13, and 14q23-q31. Genomic...Continue Reading

References

Mar 15, 1992·Cancer·J W Gray, D Pinkel
Sep 1, 1991·Cancer Genetics and Cytogenetics·J R KowalczykB Sokolowska
Oct 1, 1990·European Journal of Haematology·H J WehD K Hossfeld
Apr 1, 1989·Cancer Genetics and Cytogenetics·S A Narod, I D Dubé
May 1, 1989·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ Gray
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·S KatagiriS Tarui
Aug 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·Y MatsuokaD Pressman
Jan 1, 1981·Journal of Immunological Methods·G D Johnson, G M Nogueira Araujo
May 1, 1994·Hematological Oncology·L C Moscinski, O F Ballester
Jul 1, 1995·Cancer Genetics and Cytogenetics·J R SawyerB Barlogie
Aug 1, 1995·Cancer Genetics and Cytogenetics·R AnkathilM K Nair
Jan 1, 1995·Cytometry·S du ManoirT Cremer
Dec 1, 1994·British Journal of Haematology·M A DimopoulosR Alexanian
Aug 1, 1994·Cancer Genetics and Cytogenetics·A Pérez LosadaC Bonet
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KallioniemiF M Waldman
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H J WehD K Hossfeld

❮ Previous
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Citations

Jun 20, 2002·Cancer Genetics and Cytogenetics·Stéphanie StruskiPascale Cornillet-Lefebvre
Aug 25, 1999·Cancer Genetics and Cytogenetics·A AmielM Lishner
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y W LinF J Lu
May 7, 2002·Nature Reviews. Cancer·W Michael Kuehl, P Leif Bergsagel
Mar 6, 2003·Reviews in Clinical and Experimental Hematology·Jean-Luc Harousseau
Jul 21, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M I TiirikainenR H Jensen
Oct 2, 2002·Molecular Pathology : MP·G Pratt
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola E LeoneGareth J Morgan
May 27, 2006·Blood·Fenghuang ZhanJohn D Shaughnessy
Nov 13, 2007·Hematology/oncology Clinics of North America·Giovanni Tonon
Aug 24, 2005·British Journal of Haematology·Laura RosiñolEmili Montserrat
Aug 26, 2009·British Journal of Haematology·John D ShaughnessyBart Barlogie
Jun 12, 2003·Genes, Chromosomes & Cancer·Susan M GribbleElizabeth P Nacheva
Apr 28, 2009·Genes, Chromosomes & Cancer·Laura ChiecchioUNKNOWN UK Myeloma Forum
Mar 22, 2003·British Journal of Haematology·Christine J HarrisonKim H Orchard
Sep 15, 2007·British Journal of Haematology·Hong ChangWei Xu
Sep 7, 2006·Genes, Chromosomes & Cancer·Wee J ChngRafael Fonseca
Dec 17, 2010·Journal of Internal Medicine·H NahiG Gahrton
Jan 8, 2000·Hematology/oncology Clinics of North America·R FonsecaG W Dewald
Jun 11, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nan JiangHong Chang
Jan 12, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Seon Young KimUNKNOWN Korea Multiple Myeloma Working Party
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·John D Shaughnessy, Bart Barlogie
Feb 9, 2010·Hematology/oncology and Stem Cell Therapy·Chung-King Lin, Yung-Chuan Sung
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip R GreippJan Westin

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