Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14)

Cancer Genetics and Cytogenetics
Hege Vangstein AamotSverre Heim

Abstract

We report a case of leukemic mantle cell lymphoma of the blastoid variant with complex chromosomal rearrangements leading to the recombination of BCL1 from 11q13 and IGH from 14q32. G-banding analysis showed, in addition to multiple other chromosome abnormalities, a del(11)(q13) and addition of unknown material to chromosome arms 13p and 21p. The two latter rearrangements were revealed, by use of multicolor in situ hybridization (M-FISH) analysis, to be a der(13)(qter-->p11::14q32::11q13-->11q22::14q32-->14q11::11q22-->11qter) and a similar der(21)(qter-->p11::14q32::11q13-->11q23::14q32-->14q11::11q22-->11qter). FISH with locus-specific probes for BCL1 and IGH showed a fusion signal on both derivative chromosomes.

References

Nov 14, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·E SchletteL J Medeiros
Aug 2, 2003·European Journal of Haematology·Niels S AndersenUNKNOWN Nordic Lymphoma Group
Sep 24, 2004·Cancer Genetics and Cytogenetics·Sonia MaravelakiVasantha Brito-Babapulle

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Citations

Jan 20, 2012·Annals of Laboratory Medicine·Yoonmi SeokKyung-A Lee

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