Molecular cytogenetic analysis of recurrent unbalanced t(11;17) in neuroblastoma

Cancer Genetics and Cytogenetics
R L StallingsA O'Meara

Abstract

Loss of 11q material occurs in approximately 30% of advanced stage neuroblastoma and defines a distinct genetic subtype of this disease. These tumors almost always possess unbalanced gain of the 17q, along with many additional recurrent chromosomal imbalances. Loss of 11q and gain of 17q is often the consequence of an unbalanced translocation between the long arms of both chromosomes, but because of the involvement of other chromosomal mechanisms, the actual frequency of t(11;17) is unknown. In addition, chromosomal breakpoint positions for the t(11;17) are variable in different tumors, with breakpoints on neither the 11q nor 17q being well defined. We have used interphase fluorescence in situ hybridization analysis to detect a der(11)t(11;17) in a series of neuroblastomas with 11q loss/17q gain using a statistical approach which could be applicable to the detection of translocations in other solid tumors. The frequency of der(11)t(11;17) was approximately 90% in our neuroblastoma series. A balanced t(11;17) was also detected in a MYCN amplified tumor, which is a distinctly different genetic subtype from the 11q- tumors. Breakpoint positions on 11q were determined to be variable, whereas all breakpoints on 17q appeared to clust...Continue Reading

References

Feb 1, 1988·Cancer Genetics and Cytogenetics·E DontiP Cornaglia-Ferraris
Oct 31, 1985·The New England Journal of Medicine·R C SeegerD Hammond
Apr 1, 1995·Cancer·H Avet-LoiseauA Bernheim
Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M LastowskaN Bown
Sep 17, 1998·Genes, Chromosomes & Cancer·J VandesompeleF Speleman
Jun 22, 2000·Genes, Chromosomes & Cancer·I Janoueix-LeroseyO Delattre
Jul 24, 2001·Medical and Pediatric Oncology·M LastowskaM S Jackson
Jul 12, 2002·Genes, Chromosomes & Cancer·Maria ŁastowskaMichael S Jackson
Mar 21, 2003·Cancer Genetics and Cytogenetics·R L StallingsA O'Meara
Aug 7, 2003·The Lancet Oncology·Manfred SchwabFrank Berthold

❮ Previous
Next ❯

Citations

Jan 1, 2013·Pediatric Surgery International·Raquel Domingo-FernandezIsabella Bray
Apr 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick G BuckleyRaymond L Stallings
Nov 15, 2007·Cytogenetic and Genome Research·R L Stallings
Jun 19, 2007·Cancer Genetics and Cytogenetics·Raymond L StallingsDaijin Ko
Apr 3, 2007·Trends in Genetics : TIG·Raymond L Stallings
Apr 25, 2007·Cancer Genetics and Cytogenetics·Prakash N NairRaymond L Stallings
Mar 11, 2010·Expert Review of Molecular Diagnostics·Jennifer A LoganPhilip J R Day

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.