Molecular cytogenetic and genetic aspects of globozoospermia: a review

Andrologia
A PerrinM De Braekeleer

Abstract

Infertility is estimated to affect up to 15% of couples of reproductive age. Among the male factors, globozoospermia (also called round-headed sperm syndrome) is a rare type of teratozoospermia accounting for <0.1% of male infertility. Lack of acrosome, whose production is a postmeiotic event in spermatogenesis, and round sperm head are its main characteristics. The acrosomeless spermatozoon is unable to go through the zona pellucida and fuse with the oolemma of the oocyte, and fertilisation failures have been attributed to a deficiency in oocyte activation capacity, even when intracytoplasmic sperm injection (ICSI) is attempted. The pathogenesis of this anomaly is still unclear but genetic factors are likely to be involved. DNA fragmentation rate has been reported for 16 globozoospermic males, usually using the terminal uridine nick-end labelling (TUNEL) assay. Most of the patients had a DNA fragmentation index (DFI) higher than that in fertile men. The rate of aneuploidy for some specific chromosomes was increased in 12 among the 26 globozoospermic males reported in the literature. The same results (high DFI and aneuploidy rates) were observed in infertile males compared to fertile men, notably in those with oligoasthenozoosp...Continue Reading

References

Jan 12, 1973·Deutsche medizinische Wochenschrift·A F HolsteinJ Mauss
Dec 5, 1980·Science·D P EvensonM R Melamed
Jan 1, 1995·Reproduction, Fertility, and Development·H BourneH W Baker
Mar 1, 1996·Human Reproduction Update·H BilligA J Hsueh
Jun 1, 1997·Molecular Human Reproduction·J A Kramer, S A Krawetz
Mar 2, 1999·Reviews of Reproduction·D SakkasU Bianchi
Mar 2, 1999·Reviews of Reproduction·A P Sinha Hikim, R S Swerdloff
Jan 7, 2000·Biochemical and Biophysical Research Communications·R TakeyaH Sumimoto
Dec 1, 2000·Human Reproduction·S VivilleS Warter
Feb 7, 2001·Human Reproduction·P SutovskyG Schatten
Nov 17, 2001·Science·N Kang-DeckerJ M van Deursen
Jul 3, 2002·Human Reproduction·Hulusi Bulent ZeynelogluSertac Batioglu
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ryoji YaoTetsuo Noda
Aug 2, 2002·Human Reproduction·Enzo VicariAldo E Calogero
Jun 13, 2003·Fertility and Sterility·Renée H MartinAlfred W Rademaker
Jun 24, 2003·Advances in Experimental Medicine and Biology·Sally D PerreaultAndrew J Wyrobek
Aug 21, 2003·Human Reproduction Update·A Agarwal, Tamer M Said
Sep 28, 2004·Molecular Human Reproduction·F MorelM De Braekeleer
Nov 10, 2004·Fertility and Sterility·Zaid KilaniChristopher L R Barratt
Feb 11, 2005·Archives of Histology and Cytology·Abraham L Kierszenbaum, Laura L Tres
Feb 12, 2005·Human Reproduction·Subhash C Juneja, Jan M van Deursen
Mar 5, 2005·Human Reproduction·Olivier PirrelloStéphane Viville
Jul 13, 2005·Fertility and Sterility·Nicole DitzelKarl Sterzik
Sep 30, 2006·Human Reproduction Update·A H D M DamJ A M Kremer
Mar 9, 2007·Annals of Saudi Medicine·M A KhaliliM Ghafour-Zadeh

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Citations

Dec 5, 2014·Reproduction, Fertility, and Development·Daniel Vaiman
Nov 21, 2015·Human Reproduction Update·Patrizia RubinoPaola Piomboni
Oct 8, 2015·Andrology·L Chansel-DebordeauxC Jimenez
Jun 10, 2014·Proteomics·Ashling Holland, Kay Ohlendieck
Apr 19, 2015·Human Reproduction Update·Charles CouttonPierre F Ray
Feb 26, 2015·Journal of Assisted Reproduction and Genetics·Marc De BraekeleerAurore Perrin
Jun 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yoshinori KanemoriTadashi Baba
Apr 7, 2018·Nature Reviews. Urology·Csilla Krausz, Antoni Riera-Escamilla
Jun 18, 2019·Systems Biology in Reproductive Medicine·Elena MorettiCinzia Signorini
Oct 16, 2015·Proceedings. Biological Sciences·Heath A MacMillanJohannes Overgaard
Nov 15, 2019·Andrologia·Farzaneh FesahatAshok Agarwal
Dec 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hidenobu OkudaMoira K O'Bryan
Oct 24, 2019·Human Fertility : Journal of the British Fertility Society·Jacob NethertonMark Baker
Aug 16, 2019·Journal of Translational Medicine·Federica CariatiRossella Tomaiuolo
Mar 20, 2020·Journal of Assisted Reproduction and Genetics·Yousef DaneshmandpourEbrahim Sakhinia
Jan 1, 2013·Basic and Clinical Andrology·Thomas KaraouzènePierre F Ray
Jul 1, 2017·Andrologia·N EskandariM H Nasr-Esfahani
Nov 25, 2020·Annual Review of Genetics·Nahid Punjani, Dolores J Lamb
Oct 16, 2020·G3 : Genes - Genomes - Genetics·Brendan J HoustonMoira K O'Bryan
Apr 21, 2021·Journal of Assisted Reproduction and Genetics·Stephanie CheungGianpiero D Palermo

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