Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines

Cancer Genetics and Cytogenetics
K SzuhaiPancras C W Hogendoorn

Abstract

Most Ewing family tumors are identified by the characteristic translocation t(11;22)(q24;q12), resulting in a fusion protein EWS/FLI1 that acts as an aberrant transcription factor. In a minority of cases, the EWS gene is fused to another member of the ETS gene (ERG, ETV1, E1AF, and FEV). Though the oncogenic transforming capability of the EWS/FLI1 protein is highly suggestive, the exact pathway behind remains to be elucidated. The availability of cell lines may help in the understanding of underlying cellular processes. In this study, we have established two new Ewing sarcoma cell lines and characterized them with molecular cytogenetic tools. This technology was also applied on four other previously published Ewing sarcoma cell lines. Our findings in relation to previous data on similar tumors are discussed.

References

Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
Mar 1, 1997·Genes, Chromosomes & Cancer·Y KanekoN Maseki
Mar 13, 1997·Oncogene·M PeterO Delattre
Mar 27, 1999·European Journal of Human Genetics : EJHG·H J TankeJ Vrolijk
Jul 28, 2001·Cytogenetics and Cell Genetics·C M HattingerP F Ambros
Feb 28, 2003·Cancer Genetics and Cytogenetics·A Martínez-RamírezJ Benítez

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Citations

Jan 18, 2011·Cancer Immunology, Immunotherapy : CII·Emilie P BuddinghArjan C Lankester
Sep 30, 2009·Virchows Archiv : an International Journal of Pathology·Judith V M G Bovée, Pancras C W Hogendoorn
Aug 5, 2008·Diagnostic Pathology·Rosa NogueraAntonio Llombart-Bosch
Aug 10, 2010·BMC Research Notes·Stine H KresseLeonardo A Meza-Zepeda
Apr 25, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Iranzu GonzálezFernando Lecanda
Jun 16, 2009·Magnetic Resonance Imaging Clinics of North America·Sandra L Wootton-Gorges
Jul 29, 2008·Molecular Immunology·Dirk H J VerhoevenArjan C Lankester
Dec 19, 2006·Cancer Genetics and Cytogenetics·Károly SzuhaiPancras C W Hogendoorn
Apr 27, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jeroen KnijnenburgKároly Szuhai
Jul 1, 2014·The Journal of Pathology·Wietske van der EntB Ewa Snaar-Jagalska
Jul 3, 2016·Cancer Immunology, Immunotherapy : CII·Laurens G L SandPancras C W Hogendoorn
Nov 26, 2009·Virchows Archiv : an International Journal of Pathology·Salvatore Romeo, Angelo P Dei Tos
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfons S K de HoogeArjan C Lankester
Nov 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens H W PahlArjan C Lankester
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Károly SzuhaiPancras C W Hogendoorn

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