Molecular-cytogenetic characterization of non-Hodgkin's lymphoma with double and cryptic translocations of the immunoglobulin heavy chain gene

Leukemia & Lymphoma
Yumiko Kanda-AkanoMasafumi Taniwaki

Abstract

The present study aimed to characterize the clinical and molecular-cytogenetic features of non-Hodgkin's lymphoma (NHL) with double translocation of the immunoglobulin heavy chain (IGH) gene. G-banding analysis, fluorescence in situ hybridization (FISH) with the IGH (Cgamma and VH) and oncogene (c-MYC, BCL1, BCL2, and BCL6) probes, and long-distance polymerase chain reaction (LD-PCR) were performed on 6 patients with B-cell lymphoma, one with angioimmunoblastic T-cell lymphoma, and one with acute lymphoblastic leukemia (ALL) with B-cell phenotype. G-banding analysis detected two different 14q32 translocations, t(14,18) and add (14)(q32) in a patient with ALL. Two distinct partners of double IGH translocation identified by FISH were as follows: c-MYC + BCL2 in 3 patients, c-MYC + BCL1 in 2, c-MYC + BCL6 in one, BCL2 + 9q22 in one, and 1q21 + 6q27 in one. Colocalization of BCL1 and c-MYC probes was demonstrated in a patient with mantle cell lymphoma. LD-PCR detected c-MYC/Cmu, c-MYC/Calpha and BCL6/Cmu, and c-MYC/Calpha fusion in each one patient. Seven of 8 patients showed high serum LDH. Central nervous system and leukemic involvement was observed in 5 and 6 patients, respectively. Median survival time of patients with c-MYC/IG...Continue Reading

References

Jun 1, 1994·Japanese Journal of Cancer Research : Gann·H OhnoS Fukuhara
Nov 11, 1999·Leukemia·S YoshidaR Ueda
Nov 9, 2000·Leukemia·A StamatoullasH Tilly
Nov 28, 2001·British Journal of Haematology·U N VaishampayanM Palutke

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Citations

Aug 22, 2008·Postgraduate Medical Journal·G BradyP J Farrell
Jul 4, 2006·DNA Repair·Siegfried Janz
Mar 1, 2020·American Journal of Clinical Pathology·Jessica B ZiembaSaja Asakrah
Aug 26, 2011·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Masafumi Taniwaki
Aug 30, 2008·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kenichi Nomura

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