Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion)

Human Pathology
Malin NilssonNils Mandahl

Abstract

Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare tumorous lesion with aggressive growth that affects primarily the small tubular bones in the distal extremities and often recurs after excision. No previous cytogenetic data on BPOP are available. In the present study, lesions from 5 patients were investigated by chromosome banding and fluorescence in situ hybridization (FISH) analyses. Patient age ranged from 24 to 46 years, and the lesions were located in the fingers in 4 cases and in a toe in 1 case. Histological sections from all 5 tumors were characterized by a mixture of hypercellular cartilage, cancellous bone, and spindle cell components. Samples from 2 patients were available for cytogenetic analysis. One of these showed a normal female karyotype, and the other revealed a balanced translocation, t(1;17)(q32;q21), as the sole anomaly. The translocation was further characterized by 3-color metaphase FISH analyses, using 17 1q32-specific and 18 17q21-specific bacterial artificial chromosome probes, to map the precise location of the breakpoints. Split signals were detected by the RP11-99A19 probe in chromosome 1 and by the RP11-219F9 probe in chromosome 17. To determine whether these re...Continue Reading

References

Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
Jan 1, 1990·Archives of Orthopaedic and Trauma Surgery·B G LindequeP A Fourie
Apr 1, 1983·The American Journal of Surgical Pathology·F E NoraJ W Beabout
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Ioannis PanagopoulosNils Mandahl
Jan 31, 2003·Genes, Chromosomes & Cancer·Ulrike GamerdingerJochen Harbott

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Citations

Sep 1, 2010·Expert Opinion on Medical Diagnostics·Brendan C Dickson, Rita A Kandel
Aug 27, 2016·Der Orthopäde·C HartogM Wiewiorski
Feb 26, 2010·The Journal of Hand Surgery, European Volume·D Baumhoer, G Jundt
Feb 6, 2008·Journal of Shoulder and Elbow Surgery·Marianna VlychouNikolas A Athanasou
May 3, 2011·Clinical Orthopaedics and Related Research·Jibu JosephAshish Mahendra
Feb 1, 2011·Clinical Orthopaedics and Related Research·Peter Michael ProdingerJoachim Lauen
Jun 28, 2006·Clinical Orthopaedics and Related Research·Mihir M ThackerSean P Scully
Oct 5, 2006·Skeletal Radiology·W C BellG P Siegal
Jun 1, 2005·Virchows Archiv : an International Journal of Pathology·Makoto EndoTadakazu Shimoda
Oct 9, 2009·Irish Journal of Medical Science·A MohammadM Phelan
Sep 3, 2010·Der Orthopäde·D AdlerC-E Heyde
May 12, 2007·Skeletal Radiology·J Bernard BushMark S Meyer
Apr 22, 2011·Skeletal Radiology·Akio SakamotoYukihide Iwamoto
Jul 20, 2011·The Journal of Bone and Joint Surgery. British Volume·O BerberT W R Briggs
Jul 28, 2016·The Journal of Hand Surgery Asian-Pacific Volume·Vasileios A KontogeorgakosSokratis Varitimidis
Feb 13, 2015·Journal of the American Podiatric Medical Association·Crystal HolmesJames S Wrobel
Jul 9, 2020·International Journal of Surgical Pathology·Laura S Hiemcke-JiwaUta Flucke
Nov 19, 2009·Acta Orthopaedica. Supplementum·Thor AlvegårdAnders Rydholm
Jun 18, 2019·Journal of Cutaneous Pathology·Ivy Ah-Yu ChungBoštjan Luzar
Jan 17, 2014·Histopathology·Florian PulsD Chas Mangham
Mar 27, 2013·Clinical Orthopaedics and Related Research·Paul RothenbergSheila A Conway
Feb 20, 2019·Journal of Orthopaedic Surgery·Shinsuke TakedaKo Kato
Jul 3, 2020·The Journal of Hand Surgery·Sergio Martínez ÁlvarezKevin J Little
Nov 25, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rumpa Ganguly, Richard C Jordan
Apr 4, 2008·Archives of Pathology & Laboratory Medicine·Andrew E Rosenberg
Jun 27, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Feng ZhangJie Min

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