Molecular cytogenetic evidence of t(14;18)(IGH;BCL2) in a substantial proportion of primary cutaneous follicle center lymphomas

The American Journal of Surgical Pathology
Berthold StreubelAndreas Chott

Abstract

In contrast to nodal follicular lymphoma, limited data exist on genetic changes in primary cutaneous follicular lymphoma (primary cutaneous follicle center lymphoma according to WHO-EORTC). The detection rate of the BCL2 rearrangement, representing the characteristic t(14;18)(q32;q21) underlying follicular lymphoma, by polymerase chain reaction (PCR) has been reported to vary over a wide range (0%-41%), and only a few cases have been studied by molecular cytogenetic techniques such as fluorescence in situ hybridization (FISH). In this study, 27 primary cutaneous follicle center lymphomas were analyzed by FISH and the results compared with those obtained by PCR. FISH demonstrated translocations affecting the immunoglobulin heavy chain locus (IGH) in 14 of 27 cases (52%): a t(14;18)(q32;q21) involving BCL2 was found in 11 cases (41%), a t(3;14)(q27;q32) affecting BCL6 in 2 cases (7%), and in 1 case the partner gene of IGH could not be identified. Interestingly, PCR did not detect BCL2 rearrangement in any case. These data suggest that the t(14;18)(q32;q21) frequently occurs in primary cutaneous follicular lymphoma. The reason(s) why BCL2 rearrangements escape the detection by PCR is (are) not clear but could be due to BCL2 mutati...Continue Reading

References

Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M PoetschB Schlegelberger
Sep 1, 1996·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·T S FrankE D Hsi
Jan 1, 1997·Kidney & Blood Pressure Research·M E Safar, G M London
Sep 4, 1999·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M FödingerA Chott
May 1, 2001·Archives of Dermatology·L Cerroni, H Kerl
Apr 12, 2001·The British Journal of Dermatology·F J ChildS J Whittaker
Jun 23, 2001·The American Journal of Surgical Pathology·R FrancoM A Piris
Sep 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N S AguileraS L Abbondanzo
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I MirzaE D Hsi
May 23, 2002·The American Journal of Surgical Pathology·John R GoodladUNKNOWN Scotland and Newcastle Lymphoma Group
Feb 8, 2003·International Journal of Surgical Pathology·M KojimaN Masawa
Jan 17, 2004·The American Journal of Dermatopathology·Bernd LeinweberLorenzo Cerroni
May 29, 2004·The American Journal of Surgical Pathology·Béatrice VergierJean-Philippe Merlio

❮ Previous
Next ❯

Citations

Dec 14, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C HallermannH-J Schulze
Aug 18, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katsuyoshi TakataTadashi Yoshino
Oct 7, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J ValencakM Raderer
Jun 27, 2007·The American Journal of Surgical Pathology·Chris M BaconAhmet Dogan
Oct 3, 2008·The American Journal of Surgical Pathology·Chris M BaconPeter G Isaacson
Dec 10, 2008·The American Journal of Surgical Pathology·Olga K WeinbergDaniel A Arber
Dec 6, 2012·Pathology Research International·Philipp W Raess, Adam Bagg
Apr 22, 2011·Indian Journal of Dermatology, Venereology and Leprology·S KondaM Mahalingam
Apr 1, 2014·Journal of the American Academy of Dermatology·Alya Abdul-WahabSean Whittaker
Feb 27, 2009·The Journal of Investigative Dermatology·Razieh Soltani-ArabshahiAnne Janin
Mar 8, 2011·British Journal of Haematology·Carlos Fernández de LarreaArmando López-Guillermo
Jan 26, 2010·Actas dermo-sifiliográficas·L Cerroni, T Wiesner
Jun 30, 2015·Human Pathology·Beenu ThakralL Jeffrey Medeiros
Apr 22, 2016·Current Hematologic Malignancy Reports·Meenal KheterpalSteven M Horwitz
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ana-Iris SchmatzAndreas Chott
Jul 1, 2016·Journal of Cutaneous Medicine and Surgery·Houda BahigDavid Roberge
Jul 3, 2008·British Journal of Cancer·S SagmeisterB Grasl-Kraupp
Feb 20, 2015·American Journal of Clinical Pathology·Anne Pham-LedardMarie Beylot-Barry
Mar 4, 2008·Virchows Archiv : an International Journal of Pathology·Marc-Antoine Belaud-RotureauJean-Philippe Merlio
Jul 25, 2019·Archives of Pathology & Laboratory Medicine·Alejandro A GruAndrea L Salavaggione
Jun 3, 2018·Virchows Archiv : an International Journal of Pathology·Ambrus GángóÁgota Szepesi
Apr 3, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Alejandro A Gru, Louis P Dehner
May 16, 2020·Frontiers in Oncology·Alessandro PileriNicola Pimpinelli
May 23, 2007·Archives of Pathology & Laboratory Medicine·Dinesh S Rao, Jonathan W Said
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Russell A HigginsMarsha C Kinney
Aug 8, 2008·Archives of Pathology & Laboratory Medicine·Keni GuRobert C Hawley

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.