PMID: 9531643May 23, 1998Paper

Molecular cytogenetic study on four human esophageal cancer cell lines

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
F XiaoM Wu

Abstract

To investigate the possible involvement of chromosome abnormalities in pathogenesis of human esophageal cancer. Four cell lines of human esophageal cancer (EC) established in our laboratory were analysed using interphase fluorescence in situ hybridization (FISH), chromosome painting technique and comparative genomic hybridization (CGH). Chromosome gain of 1,2,3,8,16, 17, and 20 was found in the four cell lines, and loss of chromosome Y in cell line EC8712, EC8733 and EC8501 was noted. Other frequent changes were partial deletion of 1p, translocation of 2q and amplification of 5p in all 4 cell lines, and amplification of 8q and 13q in EC8733 and deletion of 17p in EC8712. The data suggest that nonrandom chromosome aberrations may play an important role in the pathogenesis of human esophageal cancer.

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