Molecular demultiplexer as a terminator automaton

Nature Communications
Ilke S TuranEngin U Akkaya

Abstract

Molecular logic gates are expected to play an important role on the way to information processing therapeutic agents, especially considering the wide variety of physical and chemical responses that they can elicit in response to the inputs applied. Here, we show that a 1:2 demultiplexer based on a Zn2+-terpyridine-Bodipy conjugate with a quenched fluorescent emission, is efficient in photosensitized singlet oxygen generation as inferred from trap compound experiments and cell culture data. However, once the singlet oxygen generated by photosensitization triggers apoptotic response, the Zn2+ complex then interacts with the exposed phosphatidylserine lipids in the external leaflet of the membrane bilayer, autonomously switching off singlet oxygen generation, and simultaneously switching on a bright emission response. This is the confirmatory signal of the cancer cell death by the action of molecular automaton and the confinement of unintended damage by excessive singlet oxygen production.

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Citations

May 31, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Chin Siang KueHong Boon Lee
Oct 12, 2018·Chemical Communications : Chem Comm·Miguel A RomeroUwe Pischel
Jun 12, 2018·Angewandte Chemie·Benjamin M LubyGang Zheng
Jul 11, 2019·Angewandte Chemie·Greta LindenOlalla Vazquez
Dec 18, 2019·Chemistry : a European Journal·Josué JiménezSantiago de la Moya
Jul 29, 2020·Chemical Communications : Chem Comm·Beatriz de LuisRamón Martínez-Máñez
Oct 16, 2019·Chemical Communications : Chem Comm·Esma UcarEngin U Akkaya
May 21, 2019·Frontiers in Chemistry·Linor Unger-AngelDavid Margulies
Apr 10, 2019·Chemical Communications : Chem Comm·Glenn J ScerriDavid C Magri
Nov 17, 2020·Chemical Communications : Chem Comm·Seylan AyanEngin U Akkaya
Nov 14, 2020·Organic & Biomolecular Chemistry·Gulsen TurkogluSundus Erbas-Cakmak
Jun 29, 2021·Frontiers in Chemistry·Gurcan GunaydinSeylan Ayan
Aug 6, 2021·Chemical Science·Gulsen TurkogluSundus Erbas-Cakmak
Aug 21, 2018·The Journal of Physical Chemistry Letters·Yao LiSuotang Jia
Aug 29, 2019·ACS Omega·Mediha Nur Zafer YurtSundus Erbas-Cakmak

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Methods Mentioned

BETA
flow cytometry
nuclear magnetic resonance

Software Mentioned

FACS
FACS Diva
DEMUX

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