Molecular depth profiling with cluster ion beams

The Journal of Physical Chemistry. B
Juan ChengNicholas Winograd

Abstract

Peptide-doped trehalose thin films have been characterized by bombardment with energetic cluster ion beams of C60+ and Aux+ (x = 1, 2, 3). The aim of these studies is to acquire information about the molecular sputtering process of the peptide and trehalose by measurement of secondary ion mass spectra during erosion. This system is important since uniform thin films of approximately 300 nm thickness can be reproducibly prepared on a Si substrate, allowing detailed characterization of the resulting depth profile with different projectiles. The basic form of the molecular ion intensity as a function of ion dose is described by a simple analytical model. The model includes parameters such as the molecular sputtering yield, the damage cross section of the trehalose or the peptide, and the thickness of a surface layer altered by the projectile. The results show that favorable conditions for successful molecular depth profiling are achieved when the total sputtering yield is high and the altered layer thickness is low. Successful molecular depth profiles are achieved with all of the cluster projectiles, although the degree of chemical damage accumulation was slightly lower with C60. With C60 bombardment, the altered layer thickness o...Continue Reading

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Citations

Jan 21, 2009·Analytical and Bioanalytical Chemistry·A WucherN Winograd
Aug 4, 2009·Analytical and Bioanalytical Chemistry·Andreas Wucher, Nicholas Winograd
Aug 12, 2009·Analytical and Bioanalytical Chemistry·John S Fletcher, John C Vickerman
Mar 26, 2013·Journal of the American Society for Mass Spectrometry·Sarah Trimpin, Ellen D Inutan
Nov 23, 2006·Journal of the American Society for Mass Spectrometry·Juan ChengNicholas Winograd
Feb 23, 2008·Journal of the American Society for Mass Spectrometry·Leiliang ZhengNicholas Winograd
Mar 12, 2010·Journal of the American Society for Mass Spectrometry·Michael E KurczyAndrew G Ewing
May 17, 2007·Analytical Chemistry·Michael F RussoBarbara J Garrison
Jul 13, 2011·Analytical Chemistry·Dan MaoAndreas Wucher
Jun 14, 2008·Analytical Chemistry·Joseph KozoleNicholas Winograd
Sep 10, 2008·Analytical Chemistry·Leiliang ZhengNicholas Winograd
Feb 21, 2009·Analytical Chemistry·Barbara J GarrisonNicholas Winograd
Dec 9, 2009·Analytical Chemistry·Dan MaoNicholas Winograd
Aug 24, 2012·Chemical Reviews·Jobin CyriacR G Cooks
Jan 9, 2010·Annual Review of Physical Chemistry·Nicholas Winograd, Barbara J Garrison
Oct 13, 2006·Journal of Biology·Peter Williams
Jun 11, 2014·Journal of the American Society for Mass Spectrometry·Rasmus HavelundIan S Gilmore
Apr 26, 2011·Journal of Proteomics·Tyler GreerLingjun Li
Jun 15, 2011·Biochimica Et Biophysica Acta·Melissa K Passarelli, Nicholas Winograd
Apr 19, 2008·Mass Spectrometry Reviews·Barbara J Garrison, Zbigniew Postawa
Sep 14, 2011·Rapid Communications in Mass Spectrometry : RCM·Yun-Wen YouJing-Jong Shyue
May 19, 2009·Mass Spectrometry Reviews·Christine M Mahoney
Nov 23, 2013·Mass Spectrometry Reviews·Claudia BichAlain Brunelle
Jan 8, 2014·Rapid Communications in Mass Spectrometry : RCM·Andreas WucherNicholas Winograd
Nov 1, 2016·Journal of the American Society for Mass Spectrometry·Quentin P VanbellingenFrancisco A Fernandez-Lima
Nov 1, 2016·Journal of the American Society for Mass Spectrometry·Hua TianNicholas Winograd
Jun 15, 2011·Current Opinion in Chemical Biology·John S FletcherNicholas Winograd
Nov 1, 2016·Journal of the American Society for Mass Spectrometry·Yufan ZhouZihua Zhu
Dec 10, 2016·Rapid Communications in Mass Spectrometry : RCM·Soheila Naderi-GoharHeng-Yong Nie
Mar 1, 2018·Annual Review of Analytical Chemistry·Nicholas Winograd
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Nov 29, 2008·Rapid Communications in Mass Spectrometry : RCM·Felicia M GreenMartin P Seah
Jan 30, 2009·Rapid Communications in Mass Spectrometry : RCM·Nunzio TuccittoAntonino Licciardello
Feb 16, 2010·Rapid Communications in Mass Spectrometry : RCM·Tim M BrewerGreg Gillen

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