Molecular design of proneurogenic and neuroprotective compounds-allosteric NMDA receptor modulators

Doklady. Biochemistry and Biophysics
D S KarlovN S Zefirov

Abstract

N-Methyl-D-aspartic acid (NMDA) receptor is a promising target for treatment of neurodegenerative diseases and other brain disorders as well as for designing proneurogenic compounds able to stimulate neurogenesis in adult brain. We analyzed the structure of the binding site of negative allosteric modulators in the amino-terminal domain of the NMDA receptor and identified possible modes of their binding as well as performed molecular design of new modulators that significantly differ from the known ones in structure and binding mode. In addition, we formed a focused library of chemical compounds with potential neuroprotective and proneurogenic properties, desirable set of pharmacokinetic properties, and low toxicity, which can be the basis for development of new-generation drugs.

References

Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Jun 7, 2012·Journal of Computer-aided Molecular Design·Mark McGann
Jul 14, 2012·Biochemical and Biophysical Research Communications·D S KarlovN S Zefirov
Sep 18, 2012·Biochimica Et Biophysica Acta·Roland Faigle, Hongjun Song
Sep 27, 2012·Expert Opinion on Therapeutic Patents·Rose M SantangeloDennis C Liotta
Feb 12, 2013·Cellular and Molecular Life Sciences : CMLS·Jean-Claude Platel, Wolfgang Kelsch
Mar 13, 2013·Doklady. Biochemistry and Biophysics·E V RadchenkoV M Pentkovski
Dec 24, 2013·Progress in Neurobiology·Ted Weita LaiYu Tian Wang
Feb 26, 2016·Molecular Pharmacology·David StroebelJayvardhan Pandit
Nov 7, 2016·Doklady. Biochemistry and Biophysics·A S DyabinaN S Zefirov

❮ Previous
Next ❯

Citations

Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eugene V RadchenkoVladimir A Palyulin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Fred H Gage
European Archives of Psychiatry and Clinical Neuroscience
Eberhard Fuchs
© 2022 Meta ULC. All rights reserved