Molecular detection and phylogenetic analysis of hepatitis E virus strains circulating in wild boars in south-central Italy

Transboundary and Emerging Diseases
G ApreaG Fusco

Abstract

Hepatitis E virus (HEV) is a zoonotic pathogen with a worldwide distribution, and infects several mammalian species, including pigs and wild boars, which are recognized as its natural reservoirs. The virus causes a usually self-limiting liver disease with a mortality rate generally below 1%, although mortality rates of 15%-25% have been recorded in pregnant woman. Chronic infections can also occur. The prevalence of HEV has been extensively studied in wild boars and pigs in northern Italy, where intensive pig herds are predominantly located. In contrast, few data have been collected in south-central Italy, where small pig herds are surrounded by large regional parks populated with heterogeneous wild fauna. In this study, 291 liver samples from wild boars caught in south-central Italy were analysed with the molecular detection of viral RNA. Our results confirm the circulation of HEV in these animals, with a mean prevalence of 13.7% (40 of 291). A nucleotide sequence analysis showed that the HEV strains were highly conserved within the same geographic areas. The wild boar HEV strains belonged to the HEV-3c subtype, which is frequently described in wild boars, and to an uncommon undefined subtype (HEV-3j-like).The viral prevalence...Continue Reading

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Citations

Nov 28, 2018·Foodborne Pathogens and Disease·Maria Fredriksson-Ahomaa
Sep 13, 2019·Food and Environmental Virology·Angela Michela Immacolata MontoneIlaria Di Bartolo
Jun 28, 2019·Food and Environmental Virology·Lazar MilojevićMirjana Dimitrijević
Sep 12, 2018·Virus Genes·Luca De SabatoIlaria Di Bartolo
Feb 28, 2019·Transboundary and Emerging Diseases·Vittorio SarcheseBarbara Di Martino
Jul 25, 2019·International Journal of Environmental Research and Public Health·Giovanna FuscoFederica Boccia
Jul 25, 2020·European Journal of Public Health·Camillo MartinoFabrizio Passamonti
Dec 16, 2020·Animals : an Open Access Journal From MDPI·Andrea PalombieriBarbara Di Martino

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